Objective. The aim of this work was to investigate whether there are differences in the executive control network (ECN) between patients with Parkinson’s disease (PD) before and after deep brain stimulation (DBS) surgery and to explore how deep brain stimulation (DBS) surgery affects ECN connectivity in patients with PD. Methods. Resting-state magnetic resonance imaging (MRI) data were obtained from 23 patients with Parkinson’s disease preoperatively (pre-PD) and postoperatively (post-PD) and 14 normal controls (CN). The right dorsolateral prefrontal cortex (DLPFC) was used as the seed region of interest (ROI) to study the characteristics of the functional connectivity of the ECN in these subjects. Results. There were differences in the ECN among PD patients before and after surgery and between the CN. Compared with the CN group, the pre-PD patients showed significantly reduced functional connectivity (FC) between the DLPFC and the left inferior frontal gyrus, left precuneus, left cerebellum posterior lobe, right middle frontal gyrus, right inferior parietal gyrus, right posterior central gyrus, right precuneus, and right inferior frontal gyrus. Compared to the CN group, the post-PD patients showed significantly reduced FC between the DLPFC and left inferior frontal gyrus, left precuneus, left cerebellum posterior lobe, right middle frontal gyrus, right inferior frontal gyrus, and right parietal lobule. There is no difference in the ECN between the pre-PD patients and the post-PD patients. Conclusions. The FC of ECN in PD patients was different from that in normal controls, but the FC of the ECN in patients with PD may not be altered by DBS. This suggests that the ECN may be considered an imaging biomarker for the identification of PD but may not be a good imaging biomarker for the evaluation of DBS efficacy.

中文翻译：

---

执行控制网络能否用于诊断帕金森病并作为深部脑刺激的功效指标？

客观。这项工作的目的是调查在深部脑刺激 (DBS) 手术前后帕金森病 (PD) 患者的执行控制网络 (ECN) 是否存在差异，并探讨深部脑刺激 (DBS) 手术如何影响PD患者的ECN连接。方法。静息状态磁共振成像 (MRI) 数据来自 23 名帕金森病患者术前 (pre-PD) 和术后 (post-PD) 以及 14 名正常对照 (CN)。右背外侧前额叶皮层 (DLPFC) 被用作感兴趣的种子区域 (ROI) 来研究这些受试者中 ECN 功能连接的特征。结果. PD患者术前术后及CN间ECN存在差异。与 CN 组相比，PD 前患者的 DLPFC 与左侧额下回、左侧楔前叶、左侧小脑后叶、右侧额中回、右侧顶下回、右侧后中央的功能连接性（FC）显着降低。右楔前叶和右额下回。与 CN 组相比，PD 后患者的 DLPFC 与左侧额下回、左侧楔前叶、左侧小脑后叶、右侧额中回、右侧额下回和右侧顶叶之间的 FC 显着降低。PD前患者和PD后患者的ECN没有差异。结论. PD患者ECN的FC与正常对照组不同，但PD患者ECN的FC可能不会被DBS改变。这表明 ECN 可能被认为是识别 PD 的成像生物标志物，但可能不是评估 DBS 疗效的良好成像生物标志物。