Background: In recent times, CNTs have been much explored, and a topic of interest in science and technology and not limited to any specific field. The diverse application area included field emission, energy storage, atomic electronics, nuclear force microscopy, and imaging. In biology, CNTs engaged in developing novel tools for the delivery of biologically important molecules as well as in diverse biomedical arenas. However, despite their promise, studies of the interaction of CNTs with biological systems most often resulted in cytotoxicity at an early stage, and problems relevant to the safety and biological compatibility of CNTs are of greatest importance. The toxic effects of carbon nanotubes (CNTs) are required to be either evaded, diminished, or decreased up-to clinical acceptance level. However, rich surface chemistry that CNTs possess can be employed to functionalize them as per the specific biomedical requirements which may be useful to overcome toxicity issues.

Objective: To explore the recent reports on the functionalized CNTs for a variety of biomedical applications such as biosensing, electrochemical detection of drug, bone tissue engineering, and vitamin detection.

Results: Most of the cited articles reveal that the functionalization of CNTs may reduce its toxicity and enhance its utilization in different biological applications.

Conclusion: The review successfully frames to provide novel applications of functionalized CNTs in the biomedical arena including detection of vitamins, bone tissue engineering, electrochemical determination of drugs, and development of biosensors along with a discussion on current patent and clinical trial status of functionalized CNTs.

背景：近年来，碳纳米管已被广泛研究，并且是科学技术感兴趣的主题，并且不限于任何特定领域。广泛的应用领域包括场发射，能量存储，原子电子学，核力显微镜和成像。在生物学中，碳纳米管致力于开发新颖的工具来输送重要的生物分子以及在各种生物医学领域。然而，尽管有希望，但是碳纳米管与生物系统相互作用的研究最常在早期导致细胞毒性，与碳纳米管的安全性和生物相容性有关的问题最为重要。需要逃避，减少或降低碳纳米管（CNT）的毒性作用，直至达到临床接受水平。然而，

目的：探索有关功能化碳纳米管用于各种生物医学应用的最新报告，例如生物传感，药物的电化学检测，骨组织工程和维生素检测。

结果：大多数引用的文章揭示了碳纳米管的功能化可以降低其毒性并提高其在不同生物学应用中的利用率。

结论：该综述成功地为功能化碳纳米管在生物医学领域的新应用提供了框架，包括维生素的检测，骨组织工程，药物的电化学测定，生物传感器的开发以及功能化碳纳米管的当前专利和临床试验状态的讨论。