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Synthesis and Biological Evaluation of the Matrine Derivatives as a Novel Family of Potential Anticancer Agents
Medicinal Chemistry ( IF 2.3 ) Pub Date : 2021-05-31 , DOI: 10.2174/1573406415666191022145534 Jing Wang 1 , Hang Liu 2 , Xiao-Bin Zhuo 1 , Guang-Ming Ye 1 , Qing-Jie Zhao 1
更新日期：2021-05-24
Medicinal Chemistry ( IF 2.3 ) Pub Date : 2021-05-31 , DOI: 10.2174/1573406415666191022145534 Jing Wang 1 , Hang Liu 2 , Xiao-Bin Zhuo 1 , Guang-Ming Ye 1 , Qing-Jie Zhao 1
Affiliation
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Background: FufangKushen injection’ was a Chinese Traditional anticancer drug, which has been widely used to treat cancer in combination with other anticancer drugs.
Objective: Our goal is to synthesize a series of novel 13-dithiocarbamates matrine derivatives using matrine (1) as the lead compound, and evaluate the biological activities of the obtained compounds. Methods: The in vitro cytotoxicity of the target compounds against three human cancer cell lines (Hep3B, LM3 and BeL-7404) was evaluated. To investigate the mechanism of biological activity, cell cycle analysis was performed.
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