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C-Methylation of Organic Substrates: A Comprehensive Overview. Part I. Methane as a Methylating Agent
Mini-Reviews in Organic Chemistry ( IF 2.3 ) Pub Date : 2020-10-31 , DOI: 10.2174/1570193x16666191023143652
Saad Moulay 1
Affiliation  

A literature survey on C-methylation of organic substrates with methane as a methylating agent is analyzed. Of the substrates that undergo C-methylation are benzene, naphthalenes, toluene, alkanes, alkenes, acetonitrile, and other functionalized organic compounds. None of these methylation reactions occur in the absence of a catalyst. A direct introduction of a methyl group on the carbon sites of a molecule is concomitant with the formation of other products, as a result of either a possible rearrangement or a further reaction with methane. Mechanistically, the C-methylation with methane proceeds oxidatively. The products selectivities depend on several factors, mainly on the acid/ base character of the solid catalyst.



中文翻译:

C-有机底物的甲基化:综述。第一部分:甲烷作为甲基化剂

分析了以甲烷为甲基化剂对有机底物进行C-甲基化的文献综述。进行C-甲基化的底物是苯,萘,甲苯,烷烃,烯烃,乙腈和其他官能化的有机化合物。在没有催化剂的情况下,这些甲基化反应均不发生。由于可能的重排或与甲烷的进一步反应的结果,在分子的碳位上直接引入甲基伴随着其他产物的形成。从机理上讲,甲烷的C-甲基化是氧化进行的。产物的选择性取决于几个因素,主要取决于固体催化剂的酸/碱特性。

更新日期:2020-10-11
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