Background: Hydroxyapatite is similar to bone mineral in chemical composition and has good biocompatibility with host tissue and bone.

Objective: This work aims to tailor the mechanical and dielectric properties of hydroxyapatite with zinc substitution, to improve the wearability of implant and accelerate the healing process.

Methods: Pure and zinc incorporated hydroxyapatite Ca10(PO4)6(OH)2 samples have been successfully prepared by means of the chemical precipitation method.

Results: The results showed that hydroxyapatite(Hap) having a hexagonal structure was the major phase identified in all the samples. It was found that the secondary phase of β-tricalcium phosphate (β-TCP) formed due to the addition of zinc, resulting in biphasic structure BCP (Hap + β-TCP). A minor phase of ZnO also formed for a higher concentration of Zn (Zn ≥ 2mol%) doping. It was found that the Zn incorporation to Hap enhanced both mechanical and dielectric properties without altering the bioactive properties. The microhardness increased up to 0.87 GPa for Zn concentration equal to 1.5mol%, which is comparable to the human bone ~0.3 - 0.9 GPa. The dielectric properties evaluated in the study showed that 1.5 mol% Zn doped hydroxyapatite had the highest dielectric constant. Higher values of dielectric constant at low frequencies signify its importance in healing processes and bone growth due to polarization of the material under the influence of the electric field.

Conclusion: Sample Z1.5, having 1.5 mol% Zn doping, showed the most optimized properties suitable for bone regeneration applications.

背景：羟基磷灰石的化学成分类似于骨骼矿物质，并且与宿主组织和骨骼具有良好的生物相容性。

目的：这项工作旨在通过锌替代来定制羟基磷灰石的机械和介电性能，以改善植入物的耐磨性并加速愈合过程。

方法：采用化学沉淀法成功地制备了纯的和掺锌的羟基磷灰石Ca10（PO4）6（OH）2样品。

结果：结果表明，在所有样品中鉴定出具有六边形结构的羟基磷灰石（Hap）是主要相。发现由于添加了锌而形成了β-磷酸三钙（β-TCP）的次级相，从而导致了双相结构BCP（Hap +β-TCP）。较高浓度的Zn（Zn≥2mol％）掺杂也会形成次要的ZnO。发现将Zn结合到Hap中增强了机械性能和介电性能，而没有改变生物活性性能。当Zn浓度等于1.5mol％时，显微硬度提高到0.87 GPa，与人体骨骼〜0.3-0.9 GPa相当。研究中评估的介电性能表明1.5摩尔％Zn掺杂的羟基磷灰石具有最高的介电常数。

结论：Zn掺杂量为1.5 mol％的样品Z1.5显示出最适合骨骼再生应用的最佳性能。