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Nanostructured Titanium Alloys Surface Modification Technology for Antibacterial and Osteogenic Properties
Current Nanoscience ( IF 1.5 ) Pub Date : 2021-02-28 , DOI: 10.2174/1573413716666200217104004
Qingge Wang 1 , Laizhi Wu 2 , Shifeng Liu 1 , Peng Cao 3 , Junlin Yang 4 , Liqiang Wang 5
Affiliation  

Background: Titanium (Ti) and its alloys are potential metal materials in dental and orthopedic applications, due to their excellent mechanical properties and biocompatibility. Despite these properties, revision surgery is painful for millions of patients and may cause secondary injury, calling for a solution to this issue. Compared to antibiotics used in a clinical context, novel biomaterials display powerful application potential due to their stronger antibacterial activity, reduced drug resistance and excellent biocompatibility. Antibacterial ions have a crucial effect, particularly for nanostructured metals.

Objective: This review focuses on the antibacterial functions and osteogenic properties of surface modification based on Ag, Zn, Cu and other nonmetallic ions.

Methods: The first part of the review briefly describes the issues with bacterial infection of Ti implants. The methods of surface modification are then introduced in detail. Lastly, other strategies used to improve antibacterial and osteogenic properties are also provided.

Conclusion: Although anti-infective research is valuable, there is still a gap present between theoretical strategies and those that are clinically implemented strategies. There is an urgent need to transform the findings of research into clinical applications.



中文翻译:

纳米结构钛合金表面修饰技术的抗菌和成骨性能

背景:钛(Ti)及其合金由于其优异的机械性能和生物相容性,在牙科和整形外科应用中是潜在的金属材料。尽管具有这些特性,翻修手术仍使数百万患者痛苦不堪,并可能导致继发性损伤,因此需要针对此问题的解决方案。与临床使用的抗生素相比,新型生物材料具有更强的抗菌活性,降低的耐药性和出色的生物相容性,因此具有强大的应用潜力。抗菌离子具有至关重要的作用,特别是对于纳米结构金属。

目的:本文综述了基于Ag,Zn,Cu和其他非金属离子的表面改性的抗菌功能和成骨特性。

方法:本综述的第一部分简要介绍了钛植入物的细菌感染问题。然后详细介绍了表面改性的方法。最后,还提供了用于改善抗菌和成骨特性的其他策略。

结论:尽管抗感染研究很有价值,但理论策略与临床实施策略之间仍存在差距。迫切需要将研究结果转化为临床应用。

更新日期:2021-02-28
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