Cancer is a common disease that poses a serious threat to human health. Angiogenesis is essential for the growth and metabolism of tumors, providing oxygen and nutrition for the growth of cells and tissues. However, angiogenesis of tumors depends on the stimulation of growth factors. Vascular Endothelial Growth Factor (VEGFR) is the most unique factor. Therefore, VEGF/VEGFR targeting anticancer drugs are playing an increasingly significant role in clinical trials. In addition, it has been proved that chalcone, the precursor of natural flavonoids, has potential anti-tumor activity, especially anti-angiogenesis activity. This review summarizes the reports about the anti-angiogenesis of chalcone derivatives. Based on the chalcone skeleton, it is divided into substituted chalcones and modified chalcones. The anti-angiogenesis activities of natural or synthetic chalcones, benzene ring modified or connecting bridge modified chalcones are described in this review.

癌症是对人类健康构成严重威胁的常见疾病。血管生成对于肿瘤的生长和代谢至关重要，为细胞和组织的生长提供氧气和营养。但是，肿瘤的血管生成取决于生长因子的刺激。血管内皮生长因子（VEGFR）是最独特的因子。因此，靶向VEGF / VEGFR的抗癌药在临床试验中起着越来越重要的作用。另外，已经证明，天然类黄酮的前体查耳酮具有潜在的抗肿瘤活性，特别是抗血管生成活性。这篇综述总结了有关查尔酮衍生物的抗血管生成的报道。基于查耳酮骨架，它分为取代的查耳酮和修饰的查耳酮。