In this review, we present the recent advances in unusual novel ketosynthases catalyzing the non-decarboxylative Claisen condensations, including CsyB, MxnB/CorB, Ppys and StlD. The differences are summarized between these non-decarboxylative ketosynthases and the typical decarboxylative ketosynthases. Furthermore, the detailed enzymatic characteristics, structural basis, and catalytic mechanismof these novel ketosynthasesare described. Finally, the prospect of these kind of ketosynthases is discussed.

中文翻译：

---

新型酮合酶催化非脱羧克莱森缩合反应

在这篇综述中，我们介绍了催化非脱羧性克莱森缩合的不寻常的新型酮合成酶的最新进展，其中包括CsyB，MxnB / CorB，Ppys和StlD。总结了这些非脱羧酮合酶与典型脱羧酮合酶之间的差异。此外，描述了这些新的酮合成酶的详细的酶学特性，结构基础和催化机理。最后，讨论了这类酮基合酶的前景。