Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

杂环化合物因其不同的生物活性而众所周知。杂环类似物是有机化学中药物活性化合物合成的基础。这些衍生物显示出各种类型的生物活性，例如抗癌，抗炎，抗微生物，抗惊厥，抗疟疾，抗高血压等。从最近的十年研究表明，喹啉类似物在新型药物的开发中起着至关重要的作用。用于治疗各种疾病的药物活性化合物。喹啉具有抗病毒，抗癌，抗微生物和抗炎的活性。这篇综述将总结各种合成喹啉衍生物并检查其生物学活性的方法。