Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper.

香豆素和恶二唑部分普遍存在于多种天然产物中，并因其多样而有益的药理活性而受到重视。本文中，本综述着重于研究人员用于合成各种具有生物活性的香豆素-恶二唑支架的各种文献技术。同样，讨论的通用技术被用于建立合成香豆素和恶二唑衍生物的广泛的生物活性，包括：抗氧化剂，驱虫药，抗微生物药，抗结核药，止痛药，抗炎药，细胞毒性药和抗惊厥药。此外，本文还重点介绍了在常规临床实践中通常分配的使用香豆素-恶二唑支架合成的现有药物。