Same-sex couples, not unlike their heterosexual counterparts, would prefer having a genetically related child. However, assisted same-sex human reproduction has heretofore been deemed infeasible absent haploid cellular analogs of human gametes. Recent developments, however, may have overcome this limitation through the derivation of haploid embryonic stem cells (hapESCs). Undifferentiated, pluripotent, self-renewing, and stably haploid, hESCs have also displayed germline competence. It is in this capacity that murine hESCs, doubling up as de facto gametes, gave rise to bimaternal and bipaternal progeny. Herein we argue that assisted same-sex human reproduction, although potentially attainable at this time, is still years away from the clinic. In support of this perspective, we note the significant technical, regulatory, statutory, and societal hurdles that stand in the way of near-term implementation.

中文翻译：

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辅助同性生殖：单倍体干细胞的前景？

同性伴侣与异性恋伴侣没有什么不同，他们更喜欢有一个基因相关的孩子。然而，迄今为止，人类配子的单倍体细胞类似物的辅助同性人类繁殖被认为是不可行的。然而，最近的发展可能已经通过衍生单倍体胚胎干细胞 (hapESCs) 克服了这一限制。未分化、多能、自我更新和稳定单倍体的 hESC 也显示出生殖能力。正是在这种能力下，小鼠 hESC 加倍成为事实上的配子，产生了双母和双父后代。在此，我们认为辅助同性人类生殖虽然此时可能实现，但距离临床仍有数年之遥。为支持这一观点，我们注意到重要的技术、监管、法定、