Background. Inflammation and tumorigenesis are related. We conducted this study to evaluate whether inflammatory factors (IFs) have a diagnostic value for pathology and a predictive value for survival and recurrence in bladder cancer patients undergoing total cystectomy. Methods. The patients who were diagnosed with bladder cancer and underwent total cystectomy in our center from 2014 to 2020 were enrolled. The values of neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and systemic immune-inflammation index (SII) were calculated by blood routine test results before operation. The AUC of ROC was calculated to judge the diagnostic value of the IFs in pathology and their corresponding cut-off values. For overall survival (OS) and recurrence-free survival (RFS), the above IFs were grouped according to the cut-off value. The differences between different groups were analyzed by the Kaplan-Meier curves, and the predictive value of these IFs was determined by the Cox proportional hazards regression model. Results. A total of 79 patients were enrolled. All IFs had no diagnostic value for the pathological grade, tumor T stage, and systemic metastasis. Only NLR (, , , , ), dNLR (, , , , ), and SII (, , , , ) had a diagnostic value for lymph node metastasis. The median follow-up time was 31 months, and there was no significant difference in OS between the two groups for all IFs. For RFS, Kaplan-Meier suggested PLR might be predictive when the cut-off value was 266.70 (), but the subsequent Cox proportional hazards regression analysis showed that all IFs had no predictive value for OS and RFS. Conclusions. We found that in patients undergoing total cystectomy preoperative NLR, dNLR and SII had a diagnostic value for lymph node metastasis, while all these five IFs had no predictive value for OS and RFS. However, this conclusion needs to be further verified by large-scale studies in the future.

中文翻译：

---

炎症因子在膀胱全切术患者病理及生存中的诊断及预测价值

背景。炎症和肿瘤发生是相关的。我们进行了这项研究，以评估炎症因子 (IFs) 是否对接受全膀胱切除术的膀胱癌患者的病理学诊断和生存和复发具有预测价值。方法. 纳入2014-2020年在我中心诊断为膀胱癌并接受全膀胱切除术的患者。血常规计算中性粒细胞与淋巴细胞比值（NLR）、衍生中性粒细胞与淋巴细胞比值（dNLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）和全身免疫炎症指数（SII）操作前的测试结果。计算 ROC 的 AUC 来判断 IF 在病理学中的诊断价值及其对应的临界值。对于总生存期（OS）和无复发生存期（RFS），上述IFs根据截止值进行分组。通过Kaplan-Meier曲线分析不同组之间的差异，并通过Cox比例风险回归模型确定这些IF的预测值。结果。共有 79 名患者入组。所有IF对病理分级、肿瘤T分期和全身转移均无诊断价值。只有 NLR (, , , , ), dNLR (, , , , )和 SII (, , , , )对淋巴结转移有诊断价值。中位随访时间为 31 个月，对于所有 IF，两组的 OS 无显着差异。对于 RFS，Kaplan-Meier 建议 PLR 在截止值为 266.70 时可能具有预测性（)，但随后的 Cox 比例风险回归分析表明，所有 IF 对 OS 和 RFS 没有预测价值。结论。我们发现在接受全膀胱切除术的术前 NLR 的患者中，dNLR 和 SII 对淋巴结转移具有诊断价值，而这 5 个 IF 对 OS 和 RFS 均无预测价值。不过，这一结论还需要在未来通过大规模的研究进一步验证。