Abstract

Pseudomonas aeruginosa is a gram-negative bacterium that exists in various ecosystems, causing severe infections in patients with AIDS or cystic fibrosis. P. aeruginosa can form biofilm on a variety of surfaces, whereby the bacteria produce defensive substances and enhance antibiotic-resistance, making themselves more adaptable to hostile environments. P. aeruginosa resistance represents one of the main causes of infection-related morbidity and mortality at a global level. Iron is required for the growth of P. aeruginosa biofilm. This review summarises how the iron metabolism contributes to develop biofilm, and more importantly, it may provide some references for the clinic to achieve novel anti-biofilm therapeutics by targeting iron activities.

摘要

铜绿假单胞菌是一种革兰氏阴性菌，存在于各种生态系统中，可引起艾滋病或囊性纤维化患者的严重感染。铜绿假单胞菌可以在各种表面形成生物膜，从而细菌产生防御物质并增强抗生素抗性，使其更能适应恶劣的环境。铜绿假单胞菌耐药性是全球范围内与感染相关的发病率和死亡率的主要原因之一。铜绿假单胞菌生物膜的生长需要铁。该综述总结了铁代谢如何促进生物膜的形成，更重要的是，它可能为临床通过靶向铁活性实现新型抗生物膜疗法提供一些参考。