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Accuracy of genomic selection and long‐term genetic gain for resistance to Verticillium wilt in strawberry
The Plant Genome ( IF 4.219 ) Pub Date : 2020-09-24 , DOI: 10.1002/tpg2.20054
Dominique D. A. Pincot 1 , Michael A. Hardigan 1 , Glenn S. Cole 1 , Randi A. Famula 1 , Peter M. Henry 2 , Thomas R. Gordon 3 , Steven J. Knapp 1
Affiliation  

Verticillium wilt, a soil‐borne disease caused by the fungal pathogen Verticillium dahliae, threatens strawberry (Fragaria × ananassa) production worldwide. The development of resistant cultivars has been a persistent challenge, in part because the genetics of resistance is complex. The heritability of resistance and genetic gains in breeding for resistance to this pathogen have not been well documented. To elucidate the genetics, assess long‐term genetic gains, and estimate the accuracy of genomic selection for resistance to Verticillium wilt, we analyzed a genetically diverse population of elite and exotic germplasm accessions (n = 984), including 245 cultivars developed since 1854. We observed a full range of phenotypes, from highly susceptible to highly resistant: < 3% were classified as highly resistant, whereas > 50% were classified as moderately to highly susceptible. Broad‐sense heritability estimates ranged from 0.70–0.76, whereas narrow‐sense genomic heritability estimates ranged from 0.33–0.45. We found that genetic gains in breeding for resistance to Verticillium wilt have been negative over the last 165 years (mean resistance has decreased over time). We identified several highly resistant accessions that might harbor favorable alleles that are either rare or non‐existent in modern populations. We did not observe the segregation of large‐effect loci. The accuracy of genomic predictions ranged from 0.38–0.53 among years and whole‐genome regression methods. We show that genomic selection has promise for increasing genetic gains and accelerating the development of resistant cultivars in strawberry by shortening selection cycles and enabling selection in early developmental stages without phenotyping.

中文翻译:

草莓抗黄萎病的基因组选择和长期遗传增益的准确性

黄萎病是一种由病原体大黄萎病菌引起的土壤传播疾病,威胁着全球草莓(Fragaria × ananassa)的生产。抗性品种的发展一直是一个挑战,部分原因是抗性的遗传很复杂。对这种病原体的抗性遗传力和抗性育种的遗传增益尚未得到很好的记录。为了阐明遗传学,评估长期遗传增益并估计抗黄萎病的基因组选择的准确性,我们分析了遗传多样性丰​​富的优良种和外来种质(n = 984),包括自1854年以来开发的245个品种。我们观察到了从高敏感到高耐药的完整表型:<3%被归为高耐药,而> 50%被归为中至高敏感。广义的遗传力估计值范围为0.70-0.76,而狭义的基因组遗传力估计值范围为0.33-0.45。我们发现,在过去的165年中,黄萎病抗性育种的遗传增益为负值(平均抗性随时间下降)。我们鉴定了几种可能具有现代人群中罕见或不存在的有利等位基因的高抗性种质。我们没有观察到大效果基因座的分离。历年和全基因组回归方法中,基因组预测的准确性在0.38–0.53之间。
更新日期:2020-11-21
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