Reichmann et al. (this issue, 2020)¹ show that histamine H3 receptor (Hrh3) antagonism or knockout (hrh3‐/‐) in zebrafish (Danio rerio) reduce aggressive behavior. With their projections all over the central nervous system in vertebrates, histaminergic neurons attract increasing attention in the pharmaceutical industry, especially for their inhibitory H3 receptors, coupled to Gi/o‐type proteins, autoreceptors and heteroreceptors on many other neuronal systems. The Hrh3 inverse agonist/antagonist pitolisant, recently introduced for treatment of the sleep disorder narcolepsy, reduces cataplexy and excessive day time sleepiness.

中文翻译：

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组胺抗侵略-来自鱼类的事实。

Reichmann等。（此问题，2020年）¹表明斑马鱼（Danio rerio）中的组胺H3受体（Hrh3）拮抗作用或敲除（hrh3 /-）会降低攻击行为。随着它们遍布脊椎动物中枢神经系统的投射，组胺能神经元在制药行业引起了越来越多的关注，特别是因为它们的抑制性H3受体与许多其他神经元系统上的Gi / o型蛋白，自体受体和异体受体偶联。最近引入的Hrh3反向激动剂/拮抗剂pitolisant用于治疗睡眠障碍性发作性睡病，可减少猝倒症和过多的日间嗜睡。