The strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2‐hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method‐modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH‐sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast in cell culture judged by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications.

中文翻译：

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基于甲基丙烯酸2-羟乙酯/明胶/藻酸盐/氧化铁（III）的水凝胶支架平台的姜黄素控制释放

将天然和合成来源的聚合物与无机成分结合使用的策略，以利用其独特的增效作用来开发新颖，精密，高效的3D聚合物生物材料，其结构和特性模仿细胞外基质，同时代表适合的水凝胶平台控制药物释放。新型通用的甲基丙烯酸2-羟乙酯/明胶/藻酸盐/三氧化二铁基水凝胶是通过简单但有效的方法改性的成孔作用制备的。测试了化学成分，形态，溶胀能力，孔隙率，机械性能，对细胞活力的影响以及体外降解，以使材料的成分与相应的性能相关联。水凝胶显示出相互连接的多孔微结构，令人满意的机械强度，pH敏感性和良好的姜黄素释放性能。通过3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓溴化物分析判断，该材料显示出与健康人类成纤维细胞良好的相容性，表明新合成的水凝胶可能是新一代的3D生物材料，具有可调性适用于多种生物医学和制药应用。