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L−Lysine Amino Acid Adsorption on Zeolite L: a Combined Synchrotron, X‐Ray and Neutron Diffraction Study
ChemistryOpen ( IF 2.3 ) Pub Date : 2020-09-24 , DOI: 10.1002/open.202000183
Giada Beltrami 1 , Annalisa Martucci 1 , Luisa Pasti 2 , Tatiana Chenet 2 , Matteo Ardit 1 , Lara Gigli 3 , Mirco Cescon 2 , Emmanuelle Suard 4
Affiliation  

Combined neutron and X‐ray powder diffraction techniques highlighted the sorption capacity of the acidic L zeolite towards the L‐lysine amino acid. The role of zeolite channels in the stabilization of the lysine absorbed and the effect of water on protein structure are elucidated at atomistic level. The stabilization of the L α‐helical conformation is related to strong H‐bonds between the tail aminogroups of lysine molecules and the Brønsted acid site as well as to complex intermolecular H‐bond system between water molecules, zeolite and amino acid. This finding is relevant in the catalytic synthesis of polypeptide, as well as in industrial biotechnology by qualitatively predicting binding behaviour

中文翻译:

L-赖氨酸氨基酸在沸石 L 上的吸附:联合同步加速器、X 射线和中子衍射研究

结合中子和 X 射线粉末衍射技术突出了酸性 L 沸石对 L-赖氨酸氨基酸的吸附能力。在原子水平上阐明了沸石通道在稳定吸收的赖氨酸中的作用以及水对蛋白质结构的影响。L α-螺旋构象的稳定与赖氨酸分子尾氨基与布朗斯台德酸位点之间的强氢键以及水分子、沸石和氨基酸之间复杂的分子间氢键系统有关。这一发现与多肽的催化合成以及通过定性预测结合行为的工业生物技术相关
更新日期:2020-10-02
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