Exosomes are unique biogenic nanocarriers of endocytic origin that are generated from most of the cells and found in biofluids like milk, plasma, saliva, and urine. Bovine milk represents the largest and an economic source for the production of exosomes. In recent past, the utility of the milk exosomes as drug carriers is intensified. Exosomes are emerging for delivery of both small and large therapeutics due to their biocompatibility. In this article, we highlighted the various exosomal isolation techniques, physicochemical properties, their biodistribution, and utility of milk exosomes in delivering the small drug molecules and siRNA to combat cancer.

中文翻译：

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牛奶外泌体：小分子和大分子抗癌的生物纳米载体

外泌体是一种独特的内吞来源的生物纳米载体，由大多数细胞产生，存在于牛奶、血浆、唾液和尿液等生物流体中。牛奶是生产外泌体的最大和经济来源。最近，牛奶外泌体作为药物载体的效用得到了加强。由于其生物相容性，外泌体正在出现用于递送小型和大型治疗剂。在本文中，我们重点介绍了各种外泌体分离技术、理化特性、它们的生物分布以及牛奶外泌体在递送小药物分子和 siRNA 以对抗癌症方面的效用。