SARS‐CoV‐2 infection and pregnancy has been the topic of hundreds of publications over the last several months; however, few studies have focused on the implications of infection in early pregnancy and reproductive tissues. Here, we analyzed available evidence pertaining to SARS‐CoV‐2 infection, in early pregnancy, and in reproductive tissues. We searched PubMed and Embase databases in accordance with guidelines of Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) for publications from inception to June 4, 2020. Four reviewers screened titles and abstracts and obtained full‐text articles for analysis. Sixty‐two studies were included in the review. Biological plausibility for infection with SARS‐CoV‐2 exists in testis, ovaries, and placenta as they express ACE2 receptor activity. In males, SARS‐CoV‐2 infection could lead to functional abnormalities leading to spermatogenic failure and male infertility. In females, an alteration of the ACE2 cascade via SARS‐CoV‐2 infection could lead to impairment in important follicular and luteal processes. There is also evidence of significant placental pathology in SARS‐CoV‐2 infection, but it is unclear what effects there may be for early pregnancy, though available data suggest less severe effects compared to other respiratory virus outbreaks. Further investigation is needed regarding SARS‐CoV‐2 in reproductive function and early pregnancy.

中文翻译：

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严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 及其对配子发生和早期妊娠的影响。

在过去的几个月里，SARS-CoV-2 感染和怀孕一直是数百篇出版物的主题；然而，很少有研究关注感染对早期妊娠和生殖组织的影响。在这里，我们分析了与 SARS-CoV-2 感染、妊娠早期和生殖组织有关的现有证据。我们根据系统评价和元分析的首选报告项目 (PRISMA) 指南搜索了 PubMed 和 Embase 数据库中从开始到 2020 年 6 月 4 日的出版物。四位审稿人筛选了标题和摘要，并获得了全文文章进行分析。该评价纳入了 62 项研究。SARS-CoV-2 感染的生物学合理性存在于睾丸、卵巢和胎盘中，因为它们表达 ACE2 受体活性。在男性中，SARS-CoV-2 感染可能导致功能异常，导致生精失败和男性不育。在女性中，通过 SARS-CoV-2 感染改变 ACE2 级联反应可能导致重要的卵泡和黄体过程受损。也有证据表明 SARS-CoV-2 感染存在明显的胎盘病理学，但尚不清楚对早孕可能产生的影响，尽管现有数据表明与其他呼吸道病毒爆发相比，影响较轻。需要进一步研究 SARS-CoV-2 在生殖功能和早孕方面的作用。也有证据表明 SARS-CoV-2 感染存在明显的胎盘病理学，但尚不清楚对早孕可能产生的影响，尽管现有数据表明与其他呼吸道病毒爆发相比，影响较轻。需要进一步研究 SARS-CoV-2 在生殖功能和早孕方面的作用。也有证据表明 SARS-CoV-2 感染存在明显的胎盘病理学，但尚不清楚对早孕可能产生的影响，尽管现有数据表明与其他呼吸道病毒爆发相比，影响较轻。需要进一步研究 SARS-CoV-2 在生殖功能和早孕方面的作用。