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Uptake, tissue distribution and toxicological effects of environmental microplastics in early juvenile fish Dicentrachus labrax
Journal of Hazardous Materials ( IF 13.6 ) Pub Date : 2020-09-23 , DOI: 10.1016/j.jhazmat.2020.124055
Nesrine Zitouni , Noureddine Bousserrhine , Omayma Missawi , Iteb Boughattas , Nathalie Chèvre , Raphael Santos , Sabrina Belbekhouche , Vanessa Alphonse , Floriane Tisserand , Ludivine Balmassiere , Sofia Pereira Dos Santos , Moncef Mokni , Hamadi Guerbej , Mohamed Banni

As the smallest environmental microplastics (EMPs), even at nanoscale, are increasingly present in the environment, their availability and physical and chemical effects on marine organisms are poorly documented. In the present study, we primarily investigated the uptake and accumulation of a mixture of environmental microplastics (EMPs) obtained during an artificial degradation process in early-juvenile sea bass (Dicentrarchus labrax). Moreover, we evaluated their hazardous effects using biochemical markers of cytotoxicity. Polymer distribution and composition in gill, gut, and liver were analyzed using polarized light microscopy (PLM) and Raman microspectroscopy (RMS). Our findings revealed the size-dependent ingestion and accumulation of smaller MPs (0.45-3µm) in fish tissues even after a short-term exposure (3 and 5 days). In addition to MPs, our results showed the presence of plastic additives including plasticizers, flame retardants, curing agents, heat stabilizers, and fiber-reinforced plastic materials in fish tissues, which contributed mostly to the larger-sized range (≥ 1.2µm). Our data showed that significant oxidative alterations were highly correlated with MPs size range. Our results emphasized that the toxicity of smaller EMPs (≤ 3µm) was closely related to different factors, including the target tissue, exposure duration, size range of MPs, and their chemical properties.



中文翻译:

幼鱼Dicentrachus labrax对环境微塑料的吸收,组织分布和毒理作用

由于最小的环境微塑料(EMP),即使是纳米级的,也越来越多地存在于环境中,因此,其可用性以及对海洋生物的物理和化学作用的文献很少。在本研究中,我们主要研究了在早期幼鲈(Dicentrarchus labrax)人工降解过程中获得的环境微塑料(EMPs)混合物的吸收和积累。)。此外,我们使用细胞毒性的生化标记物评估了它们的有害作用。使用偏振光显微镜(PLM)和拉曼光谱(RMS)分析g,肠道和肝脏中的聚合物分布和组成。我们的发现表明,即使经过短期暴露(3天和5天),较小的MP(0.45-3µm)在鱼组织中的摄取和积累也取决于大小。除MP之外,我们的结果还表明鱼组织中存在塑料添加剂,包括增塑剂,阻燃剂,固化剂,热稳定剂和纤维增强塑料,这主要是由于其较大的尺寸范围(≥1.2μm)。我们的数据表明,明显的氧化变化与MP的大小范围高度相关。

更新日期:2020-09-24
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