Strawberry-tree (Arbutus unedo L.) honey is expensive and difficult to characterize by melissopalinology. This study aimed to authenticate strawberry-tree (A. unedo L.) honeys from southern Europe, determining arbutin, groups of polyphenols, volatile and semivolatile compounds, as well as biological activities such as trolox equivalent antioxidant capacity, antioxidant activities against both hydroxyl (AOA) and superoxide radicals (SRS), oxygen radical absorbance capacity, anti-inflammatory activity, and antimicrobial activity against 7 microorganisms (Escherichia coli, Streptococcus mutans, Staphylococcus aureus, Aspergillus flavus, Aspergillus niger, Fusarium sp., and Penicillium commune). Arbutin, analyzed using HPLC-UV, was quantified in 83% of the samples. Polyphenols' contents were high. Norisoprenoids and benzene derivatives were the major compounds determined using gas chromatography-mass spectrometry. Theobromine was detected in 67% of samples. 2,6,6-Trimetyl-4-oxo-2-cyclohexen-1-carboxaldehyde, 3,4,5 trimethylphenol and 2-hydroxycyclopent-2-en-1-one were proposed as potential strawberry-tree floral markers. Antioxidant and anti-inflammatory activities were significant. Honeys’ extracts showed higher AOA and SRS, and better antimicrobial activities than the honeys. This study highlights the potential of strawberry-tree honeys and/or their phenolic extracts for food, pharmaceutical and cosmetic uses.

草莓树蜂蜜（Arbutus unedo L.）蜂蜜价格昂贵，难以通过黑素病临床表征。这项研究旨在鉴定来自南欧的草莓树蜂蜜（A. unedo L.）的蜂蜜，确定熊果苷，多酚类，挥发性和半挥发性化合物的种类，以及诸如trolox等效抗氧化能力，针对两种羟基（ AOA）和超氧自由基（SRS），氧自由基吸收能力，抗炎活性和对7种微生物（大肠杆菌，变形链球菌，金黄色葡萄球菌，黄曲霉，黑曲霉，镰刀菌（Fusarium sp。）和青霉属（Penicillium commune）。使用HPLC-UV分析的熊果素在83％的样品中进行了定量。多酚含量高。去甲肾上腺素和苯衍生物是使用气相色谱-质谱法测定的主要化合物。在67％的样品中检测到可可碱。提出了2,6,6-Trimetyl-4-oxo-2-cyclohexen-1-carboxaldehyde，3,4,5 trimethylphenol and 2-hydroxycyclopent-2-en-1-one作为潜在的草莓树花标记。抗氧化和抗炎活性很明显。蜂蜜的提取物显示出比蜂蜜更高的AOA和SRS，以及更好的抗菌活性。这项研究强调了草莓树蜂蜜和/或其酚类提取物在食品，药品和化妆品中的潜力。