Background

Exposure to polycyclic aromatic hydrocarbons (PAHs) is linked to abnormal lipid metabolism, but evidence regarding PAHs as risk factors for dyslipidemia is lacking.

Objective

To investigate the respective role and interaction of PAH exposure and antioxidant consumption in the risk for pediatric dyslipidemia.

Methods

We measured the concentrations of serum lipids, superoxide dismutase (SOD) and urinary hydroxylated PAHs (OH-PAHs) in 403 children, of which 203 were from an e-waste-exposed area (Guiyu) and 200 were from a reference area (Haojiang). Biological interactions were calculated by additive models.

Results

Guiyu children had higher serum triglyceride concentration and dyslipidemia incidence, and lower serum concentration of high-density lipoprotein (HDL) than Haojiang children. Elevated OH-PAH concentration, and concomitant SOD reduction, were both associated with lower HDL concentration and higher hypo-HDL risk (∑₃OH-Phes: B for lgHDL = −0.048, P < 0.01; OR for hypo-HDL = 3.708, 95% CI: 1.200, 11.453; SOD: B_T3 for lgHDL = 0.061, P < 0.01; OR_T3 for hypo-HDL = 0.168, 95% CI: 0.030, 0.941; all were adjusted for confounders). Biological interaction between phenanthrol exposure and SOD reduction was linked to dyslipidemia risk (RERI = 2.783, AP = 0.498, S = 2.537). Children with both risk factors (higher ∑₃OH-Phes and lower SOD) had 5.594-times (95% CI: 1.119, 27.958) the dyslipidemia risk than children with neither risk factors (lower ∑₃OH-Phes and higher SOD).

Conclusion

High PAH exposure combined with SOD reduction is recommended for predicting elevated risk for pediatric dyslipidemia. Risk assessment of PAH-related dyslipidemia should take antioxidant concentration into consideration.

中文翻译：

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通过降低血清SOD可以使PAH暴露与患儿血脂异常的风险增加相关

背景

暴露于多环芳烃（PAHs）与脂质代谢异常有关，但缺乏将PAHs作为血脂异常危险因素的证据。

目的

调查PAH暴露和抗氧化剂消耗在小儿血脂异常风险中的各自作用和相互作用。

方法

我们测量了403名儿童的血脂，超氧化物歧化酶（SOD）和尿液羟化PAHs（OH-PAHs）的浓度，其中203名来自电子废物暴露区域（Guiyu），200名来自参考区域（Haojiang） ）。通过加性模型计算生物相互作用。

结果

与Ha江儿童相比，贵屿儿童的甘油三酸酯浓度和血脂异常发生率更高，而高密度脂蛋白（HDL）的血清浓度更低。OH-PAH浓度升高和SOD降低均与HDL浓度降低和HDL降低风险相关（∑ ₃ OH-Phes：B对于lgHDL = -0.048，P <  0.01;或者对于hypo-HDL = 3.708， 95％CI：1.200，11.453; SOD：乙_T3为lgHDL = 0.061，P <  0.01; OR _T3为低HDL = 0.168，95％CI：0.030，0.941;所有进行了调整的混杂因素）。菲酚和SOD降低之间的生物相互作用与血脂异常风险相关（RERI = 2.783，AP = 0.498，S = 2.537）。有两种危险因素的儿童（∑₃ OH-Phes和SOD较低）的血脂异常风险比无危险因素的儿童高（5.5 ∑ ₃ OH-Phes较高且SOD较高）（5.5％）（95％CI：1.119，27.958 ）。

结论

建议将高PAH暴露量与SOD降低量相结合，以预测患儿血脂异常的风险升高。PAH相关血脂异常的风险评估应考虑抗氧化剂的浓度。