Abstract

Cryochemical modification methods are used to obtain hybrid composites of the antibacterial drug gentamicin sulfate, as well as copper and iron nanoparticles, which are promising precursors of the targeted drug delivery systems. The resulting systems are antibiotic nanoparticles of 50 to 300 nm, including copper and iron nanoparticles of 1 to 20 nm (according to the results of physicochemical analysis by IR spectroscopy, X-ray diffraction analysis, dynamic light scattering, and scanning and transmission microscopy). The composites obtained showed higher antibacterial activity against E. coli, P. aeruginosa, and B. cereus compared to the individual components.

中文翻译：

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硫酸庆大霉素与铜和铁纳米颗粒的杂化体系的低温合成和抗菌活性

摘要

低温化学修饰方法用于获得抗菌药物硫酸庆大霉素以及铜和铁纳米颗粒的杂化复合材料，这是靶向药物递送系统的有前途的前体。所得系统为50至300 nm的抗生素纳米颗粒，包括1至20 nm的铜和铁纳米颗粒（根据IR光谱，X射线衍射分析，动态光散射以及扫描和透射显微镜的理化分析结果） 。与单独的组分相比，所获得的复合材料对大肠杆菌，铜绿假单胞菌和蜡状芽孢杆菌具有更高的抗菌活性。