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Critical mass of lymphocytes for the coexistence in a chemotaxis system modeling tumor–immune cell interactions
Zeitschrift für angewandte Mathematik und Physik ( IF 2 ) Pub Date : 2020-09-24 , DOI: 10.1007/s00033-020-01405-6
Bei Hu , Youshan Tao

In a bounded smooth domain \(\Omega \subset {\mathbb {R}}^{2}\) and with a positive parameter \(\chi >0\), we consider the chemotaxis system

$$\begin{aligned} \left\{ \begin{array}{ll} u_t=\Delta u -\chi \nabla \cdot (u \nabla v), \\ v_t=\Delta v +w-v-uv, \\ w_t=\Delta w-uw + w(1-w), \end{array} \right. \end{aligned}$$

for modeling the interactions between tumor and immune cells. It is shown that for any given \(\chi >0\) and for suitably regular initial data \((u_0, v_0, w_0)\), the corresponding homogeneous Neumann initial-boundary problem admits a global classical solution that is bounded; moreover, a critical mass phenomenon was analytically observed: If \(\chi \) is appropriately small, then the solution will approach spatially constant nontrivial equilibria in the large time limit provided that \(\bar{u}_0:=|\Omega |^{-1}\int _\Omega u_0<1\), whereas the solution will converge to its large time limit \((\bar{ u}_0, 0, 0)\) in the case \(\bar{u}_0\ge 1\).



中文翻译:

在模拟肿瘤与免疫细胞相互作用的趋化系统中共存的淋巴细胞的临界质量

在有界光滑域\(\ Omega \ subset {\ mathbb {R}} ^ {2} \)中,并使用正参数\(\ chi> 0 \),我们考虑了趋化系统

$$ \ begin {aligned} \ left \ {\ begin {array} {ll} u_t = \ Delta u-\ chi \ nabla \ cdot(u \ nabla v),\\ v_t = \ Delta v + wv-uv, \\ w_t = \ Delta w-uw + w(1-w),\ end {array} \ right。\ end {aligned} $$

用于模拟肿瘤和免疫细胞之间的相互作用。结果表明,对于任何给定的\(\ chi> 0 \)和合适的常规初始数据\((u_0,v_0,w_0)\),相应的齐次Neumann初边界问题允许有界的全局经典解;此外,通过分析观察到一个临界质量现象:如果\(\ chi \)适当小,则只要\(\ bar {u} _0:= | \ Omega | ^ {-1} \ int _ \ Omega u_0 <1 \),而在\(\ bar的情况下,解决方案将收敛到其较大的时间限制\((\ bar {u} _0,0,0)\){u} _0 \ ge 1 \)

更新日期:2020-09-24
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