Magnetically guided capsule endoscopy is a promising technology for clinical application. A platform that simulates the magnetic capsule endoscope system is built to study the deformation process of the colon when its lumen suffers local forces. Force-displacement curves of the porcine large intestine under various experiment conditions, including different loading positions (haustra or taeniae coli), loading directions, colon inner pressures and specimen lengths, were measured to analyze the mechanical behavior of the intact large intestine during interactions with magnetic capsule endoscopes. In the practical application of the magnetic capsule endoscope, these data are imperative to optimize the control scheme and reduce operation risks. Based on our experiments, the taeniae coli of the intact large intestine show higher linear stiffness than the haustra, and inflation reduces the linear stiffness of the colon. Magnetic capsule with small edge radii can more easily damage or even perforate the colon. Based on our test results, we suggest that the force applied to the colon should be limited to below 17[Formula: see text]N when the capsule is actuated forward along the colon and limited to below 10[Formula: see text]N when the capsule is vertical to the colon during lesion screening.

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磁胶囊内窥镜在局部力下完整结肠变形的实验评估

磁引导胶囊内窥镜是一项很有前景的临床应用技术。搭建了一个模拟磁性胶囊内窥镜系统的平台，研究结肠管腔受局部力时的变形过程。测量了不同实验条件下猪大肠的力-位移曲线，包括不同的加载位置（haustra 或 taeniae coli）、加载方向、结肠内压和样本长度，以分析完整大肠在与磁性胶囊内窥镜。在磁性胶囊内窥镜的实际应用中，这些数据对于优化控制方案、降低操作风险是必不可少的。根据我们的实验，完整的大肠的带状大肠杆菌表现出比肠腔更高的线性刚度，并且膨胀降低了结肠的线性刚度。边缘半径小的磁性胶囊更容易损伤甚至穿孔结肠。根据我们的测试结果，我们建议当胶囊沿结肠向前驱动时，施加在结肠上的力应限制在 17[公式：见文本]N 以下，当胶囊沿结肠向前驱动时，应限制在 10[公式：见文本]N 以下。在病变筛查期间，胶囊垂直于结肠。