Myrcene (MC), an organic hydrocarbon, was found to exert anti-inflammatory, analgesic, antimutagenic and antioxidant properties. However, the protective role of MC has not been reported against neonatal asthma. Wistar rats induced with asthma were administered with MC; while asthma control and vehicle control were maintained without MC administration. At the end of the experimental period, lung histology, inflammatory cell counts, cytokine analysis, matrix protein expressions were elucidated. Rats administered with MC exerted significant (P < 0.05) defense in protecting the lung tissue with the evidenced restoration of alveolar thickening of the lung tissues. Also, the present study elicited the anti-asthmatic activity of MC, especially via modulating the extracellular matrix protein expression in the asthma-induced animals, while a significant reduction (P < 0.05) in the fibrotic markers were found in MC treated animals. Moreover, the protective effect of MC was evidenced with reduced leukocyte infiltration in BALF, hypersensitive specific IgE levels with a profound decrease in the inflammatory cytokines such as IL-2, IL-4, IL-18, and IL-21 in MC administered animals compared to the asthma-induced group. To an extent, the markers of asthmatic inflammation such as CD14, MCP-1, and TARC were also found to be attenuated in MC exposed animals. The possible application of MC is a promising drug for the treatment of asthma-mediated complications.

月桂烯（MC）是一种有机碳氢化合物，具有抗炎，镇痛，抗突变和抗氧化的特性。然而，尚未报道MC对新生儿哮喘的保护作用。哮喘诱导的Wistar大鼠接受MC治疗；而未使用MC则可维持哮喘控制和媒介控制。在实验期结束时，阐明了肺组织学，炎性细胞计数，细胞因子分析，基质蛋白表达。给予MC的大鼠表现出明显的（P <0.05）肺组织的肺泡增厚得以恢复，从而保护了肺组织。此外，本研究还引发了MC的抗哮喘活性，特别是通过调节哮喘诱发动物的细胞外基质蛋白表达，同时显着降低了哮喘的哮喘病（P 在经MC处理的动物中发现了<0.05）的纤维化标记物。此外，MC的动物中，BALF中的白细胞浸润减少，超敏特异性IgE水平降低，MC施用动物中的炎症细胞因子（如IL-2，IL-4，IL-18和IL-21）大大降低，证明了MC的保护作用。与哮喘引起的组相比。在一定程度上，还发现在暴露于MC的动物中，哮喘炎症标志物（如CD14，MCP-1和TARC）减弱了。MC的可能应用是用于治疗哮喘介导的并发症的有前途的药物。