The novel coronavirus is not only causing respiratory problems, but it may also damage the heart, kidneys, liver, and other organs; in Wuhan, 14 to 30% of COVID-19 patients have lost their kidney function and now require either dialysis or kidney transplants. The novel coronavirus gains entry into humans by targeting the ACE2 receptor that found on lung cells, which destroy human lungs through cytokine storms, and this leads to hyperinflammation, forcing the immune cells to destroy healthy cells. This is why some COVID-19 patients need intensive care. The inflammatory chemicals released during COVID-19 infection cause the liver to produce proteins that defend the body from infections. However, these proteins can cause blood clotting, which can clog blood vessels in the heart and other organs; as a result, the organs are deprived of oxygen and nutrients which could ultimately lead to multiorgan failure and consequent progression to acute lung injury, acute respiratory distress syndrome, and often death. However, there are novel protein modification tools called the QTY code, which are similar in their structure to antibodies, which could provide a solution to excess cytokines. These synthetic proteins can be injected into the body to bind the excess cytokines created by the cytokine storm; this will eventually remove the excessive cytokines and inhibit the severe symptoms caused by the COVID-19 infection. In this review, we will focus on cytokine storm in COVID-19 patients, their impact on the body organs, and the potential treatment by QTY code-designed detergent-free chemokine receptors.

中文翻译：

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COVID-19 患者的细胞因子风暴、其对器官的影响以及 QTY 代码设计的无去垢剂趋化因子受体的潜在治疗

新型冠状病毒不仅会引起呼吸系统疾病，还可能损害心脏、肾脏、肝脏等器官；在武汉，14% 到 30% 的 COVID-19 患者已经失去了肾功能，现在需要透析或肾移植。新型冠状病毒通过靶向肺细胞上的 ACE2 受体进入人体，通过细胞因子风暴破坏人体肺部，导致过度炎症，迫使免疫细胞破坏健康细胞。这就是为什么一些 COVID-19 患者需要重症监护的原因。COVID-19 感染期间释放的炎症化学物质导致肝脏产生保护身体免受感染的蛋白质。然而，这些蛋白质会导致血液凝固，从而堵塞心脏和其他器官的血管；因此，器官缺乏氧气和营养，最终可能导致多器官衰竭，继而发展为急性肺损伤、急性呼吸窘迫综合征，甚至死亡。然而，有一种称为 QTY 代码的新型蛋白质修饰工具，其结构与抗体相似，可以为过量的细胞因子提供解决方案。这些合成蛋白质可以注入体内，以结合细胞因子风暴产生的过量细胞因子；这最终将消除过多的细胞因子并抑制 COVID-19 感染引起的严重症状。在这篇综述中，我们将重点关注 COVID-19 患者的细胞因子风暴、它们对身体器官的影响，以及 QTY 代码设计的无去污剂趋化因子受体的潜在治疗。