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Continuous pressure measurement and serial micro-computed tomography analysis during injection laryngoplasty: A preliminary canine cadaveric study.
PLOS ONE ( IF 3.7 ) Pub Date : 2020-09-23 , DOI: 10.1371/journal.pone.0239544
Min-Su Kim 1 , Seongmin An 2 , Songwan Jin 2 , Taehoen Kim 3 , Tack-Kyun Kwon 4
Affiliation  

Injection laryngoplasty (IL) has been used to treat various types of glottal insufficiency. The precise volume and location of the injected materials impact the outcomes. However, exactly how increasing volumes of material are distributed is unknown. In fact, the amount of IL material required to medialize a vocal cord tends to be determined empirically. Thus, the goal of this study was to investigate the pattern of IL material distribution by checking serial micro–computed tomography (MCT) and pressure changes during ILs. This experimental study used 10 excised canine larynges. Experimental devices included the IL syringe, pressure sensor, infusion pump, fixed frame, and monitoring system. We injected calcium hydroxyapatite in the thyroarytenoid muscle; whenever 0.1 mL of material was injected, we obtained an MCT scan while simultaneously measuring the pressure. After the experiments, we performed histologic analyses. MCT analyses showed that materials initially expanded centrifugally and then expanded in all directions within the muscle. The pressure initially increased rapidly but then remained relatively constant until the point at which the materials expanded in multiple directions. Histologic analyses showed that the IL material tended to expand within the epimysium of the thyroarytenoid muscle. However, in some cases, the MCT revealed that there were leakages to the surrounding space with a corresponding pressure drop. If the IL material passes through the epimysium, leakage can occur in the surrounding space, which can account for the reduction in resistance during ILs.



中文翻译:

注射喉成形术期间的连续压力测量和串行微计算机断层扫描分析:犬尸体的初步研究。

注射喉成形术(IL)已用于治疗各种类型的声门关闭不全。注射材料的精确体积和位置会影响结果。但是,究竟如何分配越来越多的材料是未知的。实际上,介导声带所需的IL物质的量往往是凭经验确定的。因此,本研究的目的是通过检查连续显微计算机断层扫描(MCT)和IL期间的压力变化来研究IL物质分布的模式。该实验研究使用了10个切除的犬喉。实验设备包括IL注射器,压力传感器,输液泵,固定框架和监控系统。我们在甲状腺素类肌肉中注射了羟基磷灰石钙;每当注入0.1毫升材料时,我们在进行MCT扫描的同时测量了压力。实验后,我们进行了组织学分析。MCT分析表明,材料最初是离心膨胀的,然后在肌肉内向各个方向膨胀。压力最初迅速增加,但随后保持相对恒定,直到材料在多个方向上膨胀为止。组织学分析显示,IL物质倾向于在甲状腺素类肌肉的上皮内扩展。然而,在某些情况下,MCT揭示出存在泄漏到周围空间并伴有相应的压降。如果IL材料穿过上皮,则周围空间会发生泄漏,这可解释IL期间电阻的降低。我们进行了组织学分析。MCT分析表明,材料最初是离心膨胀的,然后在肌肉内向各个方向膨胀。压力最初迅速增加,但随后保持相对恒定,直到材料在多个方向上膨胀为止。组织学分析显示,IL物质倾向于在甲状腺素类肌肉的上皮内扩展。然而,在某些情况下,MCT揭示出存在泄漏到周围空间并伴有相应的压降。如果IL材料穿过上皮,则周围空间会发生泄漏,这可解释IL期间电阻的降低。我们进行了组织学分析。MCT分析表明,材料最初是离心膨胀的,然后在肌肉内向各个方向膨胀。压力最初迅速增加,但随后保持相对恒定,直到材料在多个方向上膨胀为止。组织学分析显示,IL物质倾向于在甲状腺素类肌肉的上皮内扩展。然而,在某些情况下,MCT揭示出存在泄漏到周围空间并伴有相应的压降。如果IL材料穿过上皮,则周围空间会发生泄漏,这可解释IL期间电阻的降低。压力最初迅速增加,但随后保持相对恒定,直到材料在多个方向上膨胀为止。组织学分析显示,IL物质倾向于在甲状腺素类肌肉的上皮内扩展。然而,在某些情况下,MCT揭示出存在泄漏到周围空间并伴有相应的压降。如果IL材料穿过上皮,则周围空间会发生泄漏,这可解释IL期间电阻的降低。压力最初迅速增加,但随后保持相对恒定,直到材料在多个方向上膨胀为止。组织学分析显示,IL物质倾向于在甲状腺素类肌肉的上皮内扩展。然而,在某些情况下,MCT揭示出存在泄漏到周围空间并伴有相应的压降。如果IL材料穿过上皮,则周围空间会发生泄漏,这可解释IL期间电阻的降低。MCT显示,周围空间存在泄漏,并伴有相应的压降。如果IL材料穿过上皮,则周围空间会发生泄漏,这可解释IL期间电阻的降低。MCT显示,周围空间存在泄漏,并伴有相应的压降。如果IL材料穿过上皮,则周围空间会发生泄漏,这可解释IL期间电阻的降低。

更新日期:2020-09-23
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