Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy.,The Journal of Infectious Diseases

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Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-09-22 , DOI: 10.1093/infdis/jiaa599
Chen Xi Yang ₁ , Emma Schon ₂ , Ma'en Obeidat _{1,

3} , Michael S Kobor ₄ , Lisa McEwen ₄ , Julie MacIsaac ₄ , David Lin ₄ , Richard M Novak ₅ , Fleur Hudson ₆ , Hartwig Klinker ₇ , Nila Dharan ₈ , Steve Horvath ₉ , Jean Bourbeau ₁₀ , Wan Tan _{1,

3} , Don D Sin _{1,

3} , S F Paul Man _{1,

3} , Ken Kunisaki _{11,

12} , Janice M Leung _{1,

3}

Affiliation

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
Section of Infectious Diseases, University of Illinois at Chicago, Chicago, Illinois, USA.
MRC Clinical Trials Unit, University College London, London, United Kingdom.
University of Würzburg Medical Center, Department of Internal Medicine II, Division of Infectious Diseases, Würzburg, Germany.
Kirby Institute, Sydney, Australia.
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Quebec, Canada.
Minneapolis Veterans Affairs Health Care System, Section of Pulmonary, Critical Care and Sleep Medicine, Minneapolis, Minnesota, USA.
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Whether accelerated aging develops over the course of chronic HIV infection or can be observed prior to significant immunosuppression on is unknown. We studied DNA methylation in blood to estimate cellular aging in persons living with HIV (PLWH) prior to the initiation of antiretroviral therapy.

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