The cognitive reappraisal of emotion is hypothesized to involve frontal regions modulating the activity of subcortical regions such as the amygdala. However, the pathways by which structurally disparate frontal regions interact with the amygdala remains unclear. In this study, 104 healthy young people completed a cognitive reappraisal task. Dynamic causal modeling (DCM) was used to map functional interactions within a frontoamygdalar network engaged during emotion regulation. Five regions were identified to form the network: the amygdala, the presupplementary motor area (preSMA), the ventrolateral prefrontal cortex (vlPFC), dorsolateral prefrontal cortex (dlPFC), and ventromedial prefrontal cortex (vmPFC). Bayesian Model Selection was used to compare 256 candidate models, with our winning model featuring modulations of vmPFC-to-amygdala and amygdala-to-preSMA pathways during reappraisal. Moreover, the strength of amygdala-to-preSMA modulation was associated with the habitual use of cognitive reappraisal. Our findings support the vmPFC serving as the primary conduit through which prefrontal regions directly modulate amygdala activity, with amygdala-to-preSMA connectivity potentially acting to shape ongoing affective motor responses. We propose that these two frontoamygdalar pathways constitute a recursive feedback loop, which computes the effectiveness of emotion-regulatory actions and drives model-based behavior.

中文翻译：

---

支持情绪认知重新评估的动态神经相互作用。

假设情绪的认知重估涉及调节皮质下区域（如杏仁核）活动的额叶区域。然而，结构上不同的额叶区域与杏仁核相互作用的途径仍不清楚。在这项研究中，104 名健康的年轻人完成了一项认知重新评估任务。动态因果建模 (DCM) 用于映射在情绪调节期间参与的额杏仁核网络内的功能交互。确定了五个区域以形成网络：杏仁核、补充前运动区 (preSMA)、腹外侧前额叶皮层 (vlPFC)、背外侧前额叶皮层 (dlPFC) 和腹内侧前额叶皮层 (vmPFC)。贝叶斯模型选择用于比较 256 个候选模型，我们的获奖模型具有在重新评估期间调节 vmPFC 到杏仁核和杏仁核到 preSMA 通路的特点。此外，杏仁核到前 SMA 调制的强度与习惯性使用认知重评有关。我们的研究结果支持 vmPFC 作为前额区域直接调节杏仁核活动的主要管道，杏仁核到前 SMA 的连接可能会影响正在进行的情感运动反应。我们建议这两个额杏仁核通路构成一个递归反馈回路，它计算情绪调节动作的有效性并驱动基于模型的行为。我们的研究结果支持 vmPFC 作为前额区域直接调节杏仁核活动的主要管道，杏仁核到前 SMA 的连接可能会影响正在进行的情感运动反应。我们建议这两个额杏仁核通路构成一个递归反馈回路，它计算情绪调节动作的有效性并驱动基于模型的行为。我们的研究结果支持 vmPFC 作为前额区域直接调节杏仁核活动的主要管道，杏仁核到前 SMA 的连接可能会影响正在进行的情感运动反应。我们建议这两个额杏仁核通路构成一个递归反馈回路，它计算情绪调节动作的有效性并驱动基于模型的行为。