Bone growth during childhood and puberty determines an adult’s final stature. Although several prior studies have reported that fermented oyster (FO) consisting of a high amount of gamma aminobutyric acid can be attributed to bone health, there is no research on the efficacy of FO on growth regulation and the proximal tibial growth plate. Therefore, in this study, we investigated the effect of FO oral administration on hepatic and serum growth regulator levels and the development of the proximal tibial growth plate in young Sprague-Dawley rats. Both oral administration of FO (FO 100, 100 mg/kg FO and FO 200, 200 mg/kg FO) and subcutaneous injection of recombinant human growth hormone (rhGH, 200 μg/kg of rhGH) for two weeks showed no toxicity. Circulating levels of growth hormone (GH) significantly increased in the FO 200 group. The expression and secretion of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were enhanced by FO administration. FO administration promoted the expression of bone morphogenic proteins IGF-1 and IGFBP-3 in the proximal tibial growth plate. This positive effect of FO resulted in incremental growth of the entire plate length by expanding the proliferating and hypertrophic zones in the proximal tibial growth plate. Collectively, our results suggested that oral administration of FO is beneficial for bone health, which may ultimately result in increased height.

中文翻译：

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富含伽马氨基丁酸的发酵牡蛎 (Crassostrea gigas) 增加了 Sprague-Dawley 大鼠胫骨近端生长板的长度

儿童期和青春期的骨骼生长决定了成人的最终身高。虽然之前的几项研究报告称，发酵牡蛎 (FO) 含有大量 γ 氨基丁酸可归因于骨骼健康，但没有关于 FO 对生长调节和胫骨近端生长板的功效的研究。因此，在本研究中，我们研究了口服 FO 对年轻 Sprague-Dawley 大鼠肝脏和血清生长调节剂水平以及胫骨近端生长板发育的影响。口服 FO（FO 100、100 mg/kg FO 和 FO 200、200 mg/kg FO）和皮下注射重组人生长激素（rhGH，200 μg/kg 的 rhGH）两周均未显示毒性。FO 200 组的生长激素 (GH) 循环水平显着增加。FO 给药增强了胰岛素样生长因子-1 (IGF-1) 和胰岛素样生长因子结合蛋白-3 (IGFBP-3) 的表达和分泌。FO 给药促进了胫骨近端生长板中骨形态发生蛋白 IGF-1 和 IGFBP-3 的表达。FO 的这种积极作用通过扩大胫骨近端生长板的增殖和肥大区，导致整个板长度的增量生长。总的来说，我们的结果表明口服 FO 有益于骨骼健康，最终可能导致身高增加。FO 给药促进了胫骨近端生长板中骨形态发生蛋白 IGF-1 和 IGFBP-3 的表达。FO 的这种积极作用通过扩大胫骨近端生长板的增殖和肥大区，导致整个板长度的增量生长。总的来说，我们的结果表明口服 FO 有益于骨骼健康，最终可能导致身高增加。FO 给药促进了胫骨近端生长板中骨形态发生蛋白 IGF-1 和 IGFBP-3 的表达。FO 的这种积极作用通过扩大胫骨近端生长板的增殖和肥大区，导致整个板长度的增量生长。总的来说，我们的结果表明口服 FO 有益于骨骼健康，最终可能导致身高增加。