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The role of autophagy in abdominal aortic aneurysm: protective but dysfunctional.
Cell Cycle ( IF 4.3 ) Pub Date : 2020-09-22 , DOI: 10.1080/15384101.2020.1823731
Lei Wang 1 , Shuai Liu 1 , Baihong Pan 1 , Huoying Cai 1 , Haiyang Zhou 1 , Pu Yang 1 , Wei Wang 1
Affiliation  

ABSTRACT

Autophagy, an evolutionarily conserved mechanism that promotes cell survival by recycling nutrients and degrading long-lived proteins and dysfunctional organelles, is an important defense mechanism, and its attenuation has been well documented in senescence and aging-related diseases. Abdominal aortic aneurysm (AAA), a well-known aging-related disease, has been defined as a chronic degenerative process in the abdominal aortic wall; however, the complete mechanism is unknown, and a clinical treatment is lacking. Accumulating evidence has recently revealed that numerous drugs that can induce autophagy are effective in the treatment of AAA. The purpose of this systematic review was to focus on the cross-talk between autophagy and high-risk factors and the potential pathogenesis of AAA to understand not only the host defense and pathogenesis but also potential treatments.



中文翻译:

自噬在腹主动脉瘤中的作用:保护性但功能失调。

摘要

自噬是一种进化上保守的机制,通过循环养分和降解长寿命蛋白质和功能失调的细胞器来促进细胞存活,是一种重要的防御机制,其衰减已在衰老和衰老相关疾病中得到充分证明。腹主动脉瘤 (AAA) 是一种众所周知的衰老相关疾病,已被定义为腹主动脉壁的慢性退行性过程;但其完整机制尚不清楚,缺乏临床治疗。最近越来越多的证据表明,许多可诱导自噬的药物可有效治疗 AAA。

更新日期:2020-11-25
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