Abstract

A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of Sophora alopecuroides. Their structures were determined to be (−)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (1), (−)-lupanine (2), (+)-matrine (3), (+)-sophoramine (4), (+)-lehmannine (5) and (−)-sophocarpine (6). Their structures were established by NMR, ECD and HRESIMS data analyses. Their cytotoxicity effects against five human tumor cell lines were tested by MTT assay. Compound 1 has showed a wide range of cytotoxicity activities against varied tumor cells in vitro.

中文翻译：

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一种从苦豆子种子中提取的新型生物碱

摘要

从苦豆子的种子中获得了一种新的金雀花碱型生物碱，以及五种已知的生物碱。它们的结构被确定为 (-)-N-(2'-羟基-3',5'-二叔丁基-甲苯)-cytisine ( 1 ), (-)-lupanine ( 2 ), (+) -苦参碱( 3 )、(+)-槐胺( 4 )、(+)-莱曼宁( 5 )和(-)-槐果碱( 6 )。它们的结构是通过 NMR、ECD 和 HRESIMS 数据分析确定的。通过 MTT 法测试了它们对五种人类肿瘤细胞系的细胞毒性作用。化合物1在体外对各种肿瘤细胞显示出广泛的细胞毒性活性。