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The oncogenic potential of NANOG: An important cancer induction mediator
Journal of Cellular Physiology ( IF 5.6 ) Pub Date : 2020-09-22 , DOI: 10.1002/jcp.30063 Basira Najafzadeh 1 , Zahra Asadzadeh 2 , Rohollah Motafakker Azad 3 , Ahad Mokhtarzadeh 2 , Amir Baghbanzadeh 2 , Hajar Alemohammad 1 , Mahdi Abdoli Shadbad 2 , Parisa Vasefifar 1 , Souzan Najafi 2 , Behzad Baradaran 2, 4
Journal of Cellular Physiology ( IF 5.6 ) Pub Date : 2020-09-22 , DOI: 10.1002/jcp.30063 Basira Najafzadeh 1 , Zahra Asadzadeh 2 , Rohollah Motafakker Azad 3 , Ahad Mokhtarzadeh 2 , Amir Baghbanzadeh 2 , Hajar Alemohammad 1 , Mahdi Abdoli Shadbad 2 , Parisa Vasefifar 1 , Souzan Najafi 2 , Behzad Baradaran 2, 4
Affiliation
Cancer stem cells (CSCs) are a unique population in the tumor, but they only comprise 2%–5% of the tumor bulk. Although CSCs share several features with embryonic stem cells, CSCs can give rise to the tumor cells. CSCs overexpress embryonic transcription factor NANOG, which is downregulated in differentiated tissues. This transcription factor confers CSC's stemness, unlimited self‐renewal, metastasis, invasiveness, angiogenesis, and drug‐resistance with the assistance of WNT, OCT4, SOX2, Hedgehog, BMI‐1, and other complexes. NANOG facilitates CSCs development via multiple pathways, like angiogenesis and lessening E‐cadherin expression levels, which paves the road for metastasis. Moreover, NANOG represses apoptosis and leads to drug‐resistance. This review aims to highlight the pivotal role of NANOG and the pertained pathways in CSCs. Also, this current study intends to demonstrate that targeting NANOG can dimmish the CSCs, sensitize the tumor to chemotherapy, and eradicate the cancer cells.
中文翻译:
NANOG 的致癌潜力:一种重要的癌症诱导介质
癌症干细胞 (CSC) 是肿瘤中的一个独特群体,但它们仅占肿瘤体积的 2% –5%。尽管 CSCs 与胚胎干细胞有几个共同特征,但 CSCs 可以产生肿瘤细胞。CSC 过表达胚胎转录因子NANOG,其在分化组织中下调。这种转录因子在WNT、OCT4、SOX2、Hedgehog、BMI的帮助下赋予 CSC 的干性、无限的自我更新、转移、侵袭性、血管生成和耐药性‐1 和其他复合物。NANOG通过多种途径促进CSCs的发育,如血管生成和降低E-钙粘蛋白表达水平,为转移铺平了道路。此外,NANOG 抑制细胞凋亡并导致耐药性。本综述旨在强调 NANOG 的关键作用以及 CSC 中的相关通路。此外,目前的这项研究旨在证明靶向 NANOG 可以使 CSC 变暗,使肿瘤对化疗敏感,并根除癌细胞。
更新日期:2020-09-22
中文翻译:
NANOG 的致癌潜力:一种重要的癌症诱导介质
癌症干细胞 (CSC) 是肿瘤中的一个独特群体,但它们仅占肿瘤体积的 2% –5%。尽管 CSCs 与胚胎干细胞有几个共同特征,但 CSCs 可以产生肿瘤细胞。CSC 过表达胚胎转录因子NANOG,其在分化组织中下调。这种转录因子在WNT、OCT4、SOX2、Hedgehog、BMI的帮助下赋予 CSC 的干性、无限的自我更新、转移、侵袭性、血管生成和耐药性‐1 和其他复合物。NANOG通过多种途径促进CSCs的发育,如血管生成和降低E-钙粘蛋白表达水平,为转移铺平了道路。此外,NANOG 抑制细胞凋亡并导致耐药性。本综述旨在强调 NANOG 的关键作用以及 CSC 中的相关通路。此外,目前的这项研究旨在证明靶向 NANOG 可以使 CSC 变暗,使肿瘤对化疗敏感,并根除癌细胞。