Isoform‐specific targeting: The synthesis and comparison of selective, bioorthogonal, activity‐based probes for penicillin‐binding proteins (PBPs) is reported. We demonstrate the expanded functional utility of bioorthogonal probes compared to fluorescent analogues and explore design considerations for the development of bioorthogonal probes that are applicable beyond the probes described in this work.

中文翻译：

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用于选择性标记青霉素结合蛋白的生物正交 β-内酯活性探针的比较。

亚型特异性靶向：报道了青霉素结合蛋白（PBP）的选择性、生物正交、基于活性的探针的合成和比较。我们证明了生物正交探针与荧光类似物相比的扩展功能实用性，并探索了开发生物正交探针的设计注意事项，这些探针适用于本工作中描述的探针之外。