In article number 1900840, Jianzhong Shen, Kui Zhu, and co‐workers present how many extracellular bacteria can invade and survive in epithelial cells in both in vivo and in vitro models. Once such bacteria survive in host cells, they act as “Trojan horses” to tolerate various stresses including antibiotic therapy. Such adaption endows bacteria with common tolerance to multiple antibiotics. Sublethal levels of antibiotics not only promote the production of bacterial toxins to increase bacterial invasion, but also cause mitochondrial dysfunction and retard the clearance of internalized bacteria.

中文翻译：

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抗生素治疗：抗生素的亚致死水平促进上皮细胞中细菌的持久性（Adv。Sci。18/2020）

在本文的1900840号文章中，沈建中，朱奎及其同事介绍了在体内和体外模型中，有多少细胞外细菌可以在上皮细胞中侵袭和存活。一旦此类细菌在宿主细胞中存活，它们就可以充当“特洛伊木马”来耐受各种压力，包括抗生素治疗。这种适应使细菌对多种抗生素具有共同的耐受性。亚致死水平的抗生素不仅会促进细菌毒素的产生，从而增加细菌的入侵，而且还会引起线粒体功能障碍并阻碍内在细菌的清除。