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Raman spectroscopy analysis of bone regeneration in a rat model by implantation of a Biocompatible Membrane Scaffold with and without LED Photobiomodulation (λ 945 ± 20 nm)
Vibrational Spectroscopy ( IF 2.5 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.vibspec.2020.103154
L.M. de M. Fortaleza , A.M.M. Alves , A.L.M. Maia Filho , D.C.L. Ferreira , C.L.S. Costa , V.G.F. Viana , J.Z.L.V. Santos , R.A. Oliveira , B.C. Viana , G.O.M. Gusmão , L.E.S. Soares

Abstract This study presents additional results of a new polystyrene membrane coated with collagen and norbixin (MPSNC) appliedin bone associated or not with light emitting diode (LED) photobiomodulation (PBM) for bone repair. Raman Spectroscopy analysis, which help to detect the amount of hydroxyapatite in the lesion and infer about the mineralization of defects, Scanning Electron Microscopy (SEM) and histological analysis were used to evaluate the bone repair process the rat bone after 15th and 30th days of euthanasia. The groups studied were divided in control; MPSNC; LED PBM; and MPSNC + LED PBM, respectively identified with the letters C, M, LED, MLED. After 30 days, the defects presented higher deposition of concentration of hydroxyapatite and a more compact and linear bone for LED group. The association between MPSNC and LED did not result in an improvement of the repair because a more exacerbated inflammatory process occurred, thus delaying the bone repair process.

中文翻译:

通过植入具有和不具有 LED 光生物调制 (λ 945 ± 20 nm) 的生物相容性膜支架对大鼠模型骨再生的拉曼光谱分析

摘要 本研究展示了一种新的涂有胶原蛋白和降冰糖素 (MPSNC) 的聚苯乙烯膜的额外结果,该膜应用于与发光二极管 (LED) 光生物调节 (PBM) 相关或不相关的骨修复骨。拉曼光谱分析有助于检测病变中羟基磷灰石的含量并推断缺陷的矿化,扫描电子显微镜(SEM)和组织学分析用于评估安乐死第15天和第30天后大鼠骨的骨修复过程. 所研究的组被分为对照组;MPSNC;LED PBM;和 MPSNC + LED PBM,分别用字母 C、M、LED、MLED 标识。30 天后,LED 组的缺陷呈现出更高浓度的羟基磷灰石沉积和更紧密和线性的骨骼。
更新日期:2020-11-01
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