The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy against COVID-19.

中文翻译：

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互补C5a-C5aR1 GPCR轴在COVID-19治疗中

当前由SARS-CoV-2引起的冠状病毒疾病（COVID-19）大流行是一项重大的全球健康挑战。Carvelli及其同事最近的一项研究表明，补体C5a及其受体C5aR1参与了疾病的发展，并提示C5a-C5aR1轴的阻滞可能代表了针对COVID-19的潜在治疗策略。