当前位置: X-MOL 学术Biomater. Adv. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Design, Characterization, and Modeling of a Chitosan Microneedle Patch for Transdermal Delivery of Meloxicam as a Pain Management Strategy for Use in Cattle
Biomaterials Advances ( IF 7.9 ) Pub Date : 2020-09-23 , DOI: 10.1016/j.msec.2020.111544
David A. Castilla-Casadiego , Hayden Carlton , David Gonzalez-Nino , Katherine A. Miranda-Muñoz , Raheleh Daneshpour , David Huitink , Gary Prinz , Jeremy Powell , Lauren Greenlee , Jorge Almodovar

This work describes the formulation and evaluation of a chitosan microneedle patch for the transdermal delivery of meloxicam to manage pain in cattle. Microneedle patches composed of chitosan and chitosan/meloxicam were evaluated regarding their chemical composition, uniformity of physical characteristics, capacity to penetrate the skin, and response to thermal and thermo-mechanical changes. Microneedle patches were prepared by varying the percentage of acetic acid used during solution preparation, including 90% (v/v), 50% (v/v), and 10% (v/v). In addition, drug release was assessed by modeling different percentages of penetration into the skin and the number of microneedles on the microneedle patch. Scanning electron microscopy confirmed the presence of microneedles uniformly organized on the patch surface for each percentage of acetic acid used. Fourier transform infrared spectroscopy revealed that 10% (v/v) of acetic acid in the solution was a suitable condition to preserve the characteristic bands of chitosan (amide I and amide II) and meloxicam (amine N-H stretch and C=O stretch) as compared to 90% (v/v) and 50% (v/v) of acetic acid used during the solution preparation. The resultant microneedle patches were successful in penetrating the skin in a cow’s cadaver ear. Results demonstrated that the average depth penetration measured after complete dehydration of the penetrated skin was approximately 78 ± 1 μm. Chitosan and chitosan/meloxicam microneedle patches with higher acetic acid percentages reflected greater resistance to compressive force as temperature increased. Time-dependent simulation of the transport of diluted species by COMSOL revealed that the transdermal drug delivery increases in function to the increment of the number of microneedles on the surface patch and percentage of penetration per microneedle. One patch released a drug concentration of 3.57 × 10-5 mol/m3 in the skin per week, which represents the 26.2% of what is needed for pain management in cattle, established as 1.43 × 10-4 mol/m3. These results demonstrate that chitosan/meloxicam microneedles patches may be suitable to manage pain in cattle after routine procedures.



中文翻译:

设计,表征和建模的美洛昔康经皮递送的壳聚糖微针贴片作为牛的疼痛管理策略

这项工作描述了用于经皮递送美洛昔康以控制牛的疼痛的壳聚糖微针贴片的配方和评估。评估了由壳聚糖和壳聚糖/美洛昔康组成的微针贴剂的化学组成,物理特性的均匀性,渗透皮肤的能力以及对热和热机械变化的响应。通过改变溶液制备过程中使用的乙酸百分比(包括90%(v / v),50%(v / v)和10%(v / v))来制备微针贴剂。此外,通过模拟不同的渗透到皮肤的百分比和微针贴片上的微针数量来评估药物释放。扫描电子显微镜证实,对于所使用的乙酸的每个百分比,在贴剂表面均存在均匀组织的微针。傅里叶变换红外光谱表明,溶液中10%(v / v)的乙酸是保留壳聚糖(酰胺I和酰胺II)和美洛昔康(胺NH拉伸和C = O拉伸)的特征谱带的合适条件。与溶液制备过程中使用的90%(v / v)和50%(v / v)的乙酸相比。所得的微针贴片成功穿透了牛尸体耳朵的皮肤。结果表明,渗透皮肤完全脱水后测得的平均深度渗透约为78±1μm。乙酸百分比更高的壳聚糖和壳聚糖/美洛昔康微针贴片随着温度的升高显示出对压缩力的更大抵抗力。COMSOL稀释物运输的时变模拟显示,透皮给药的功能随着表面贴片上微针数量的增加和每个微针的渗透百分比的增加而增加。一个补丁发布了3.57×10的药物浓度每周皮肤中-5 mol / m 3,占牛疼痛处理所需量的26.2%,确定为1.43×10 -4 mol / m 3。这些结果表明,壳聚糖/美洛昔康微针贴剂可能适合常规操作后减轻牛的疼痛。

更新日期:2020-09-23
down
wechat
bug