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Iron oxide nanoparticles based magnetic luminescent quantum dots (MQDs) synthesis and biomedical/biological applications: a review
Biomaterials Advances ( IF 7.9 ) Pub Date : 2020-09-23 , DOI: 10.1016/j.msec.2020.111545
Ali Tufani , Anjum Qureshi , Javed H. Niazi

Combination of quantum dots (QDs) and magnetic nanoparticles (MNPs) as magnetic quantum dots (MQDs) has a broad range of applications as multifunctional nanoscale devices in biological imaging, medical nano-diagnostics and nanomedicine. MQDs derived from iron oxide nanoparticles and QDs possess excellent superparamagnetic and fluorescent properties, respectively making them multifunctional nanoprobes because of their; (a) strong magnetic strength with tunable functionality, such as rapid and simple magnetic separation, (b) intense and stable fluorescence from QDs combined with tunable biological functionality upon QDs’ bio-activation, and (c) imaging/visualization by simple ultraviolet light exposure. These excellent features of MQD nanoprobes enable them to be used for magnetic resonance imaging (MRI) as contrast agents, nano-diagnostic systems for Point-of-Care (PoC) disease diagnosis, theranostics nanorobots and in other bio-medical applications. Most of MQDs are derived from iron based MNPs because of their abundancy, superparamagnetic properties, low cost and easy to synthesize. In this review, we present different methods employed for chemical synthesis of MQDs derived from iron oxide MNPs, their major chemical compositions and important parameters, such as precursor compositions, quantum yield and magnetic properties. The review also summarizes the most frequently used MQDs in applications such as bio-imaging, drug delivery, biosensor platforms and finally ends with future prospects and considerations for MQDs in biomedical applications.



中文翻译:

基于氧化铁纳米粒子的磁性发光量子点(MQD)合成和生物医学/生物学应用:综述

量子点(QD)和磁性纳米颗粒(MNP)的组合作为磁性量子点(MQD)在生物成像,医学纳米诊断和纳米医学中作为多功能纳米级设备具有广泛的应用。源自氧化铁纳米粒子的MQD和QD具有优异的超顺磁性和荧光特性,由于它们的存在,使其分别成为多功能纳米探针。(a)具有可调节功能的强大磁场强度,例如快速简单的磁分离;(b)量子点发出的强烈而稳定的荧光,以及量子点的生物激活后可调节的生物学功能,以及(c)通过简单的紫外线成像/可视化接触。MQD纳米探针的这些出色功能使其可以用作造影剂的磁共振成像(MRI),用于现场护理(PoC)疾病诊断,诊断学纳米机器人和其他生物医学应用的纳米诊断系统。大多数MQD都源自铁基MNP,因为它们的含量高,超顺磁性,成本低且易于合成。在这篇综述中,我们介绍了用于化学合成衍生自氧化铁MNP的MQD的不同方法,其主要化学组成和重要参数,例如前体组成,量子产率和磁性。审查还总结了生物成像,药物输送,生物传感器平台等应用中最常用的MQD,最后总结了生物医学应用中MQD的未来前景和考虑因素。大多数MQD都源自铁基MNP,因为它们的含量高,超顺磁性,成本低且易于合成。在这篇综述中,我们介绍了用于化学合成衍生自氧化铁MNP的MQD的不同方法,其主要化学组成和重要参数,例如前体组成,量子产率和磁性。审查还总结了生物成像,药物输送,生物传感器平台等应用中最常用的MQD,最后总结了生物医学应用中MQD的未来前景和考虑因素。大多数MQD都源自铁基MNP,因为它们的含量高,超顺磁性,成本低且易于合成。在这篇综述中,我们介绍了用于化学合成衍生自氧化铁MNP的MQD的不同方法,其主要化学组成和重要参数,例如前体组成,量子产率和磁性。审查还总结了生物成像,药物输送,生物传感器平台等应用中最常用的MQD,最后总结了生物医学应用中MQD的未来前景和考虑因素。它们的主要化学组成和重要参数,例如前体组成,量子产率和磁性。审查还总结了生物成像,药物输送,生物传感器平台等应用中最常用的MQD,最后总结了生物医学应用中MQD的未来前景和考虑因素。它们的主要化学组成和重要参数,例如前体组成,量子产率和磁性。审查还总结了生物成像,药物输送,生物传感器平台等应用中最常用的MQD,最后总结了生物医学应用中MQD的未来前景和考虑因素。

更新日期:2020-09-23
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