Hyperthermia is one of the methods for cancer therapies by creating artificial fever. Protection of healthy tissues around the tumor tissue, which has a high temperature, is one of the major issues in this treatment. In present study, the two-dimensional transient model of biological tissue with a tumor is taken into account. The area of the tumor is embedded with micro/nano superparamagnetic materials, and the surrounding healthy tissues are embedded with microcapsules of micro/nano-phase-change materials (PCMs). The effect of concentrations, the radius of the microcapsule, the melting temperature and latent heat of phase-change nanoparticles and also superparamagnetic nanoparticles on thermal protection were examined numerically by using the finite difference method. The results showed that the use of PCMs causes sensible decreases in temperatures of the healthy tissue around the cancerous cells (in some places up to 3 ℃) that leads to treatment complications reduction. If the protection of healthy tissues is well done, it is possible to raise the temperature of the cancerous tissue to achieve more favorable treatment.

中文翻译：

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基于 FDM 的微/纳米相变材料热疗癌症治疗的二维数值研究

热疗是通过制造人工发热来治疗癌症的方法之一。保护具有高温的肿瘤组织周围的健康组织是该治疗的主要问题之一。在目前的研究中，考虑了具有肿瘤的生物组织的二维瞬态模型。肿瘤区域嵌入微/纳米超顺磁材料，周围健康组织嵌入微/纳米相变材料（PCMs）微胶囊。使用有限差分法数值研究了浓度、微胶囊半径、相变纳米颗粒和超顺磁性纳米颗粒的熔化温度和潜热对热保护的影响。结果表明，使用 PCM 会导致癌细胞周围健康组织的温度显着降低（在某些地方高达 3 ℃），从而减少治疗并发症。如果健康组织的保护做得好，就有可能提高癌变组织的温度，达到更有利的治疗效果。