Abstract

Oxytocin represents one of the key element regulating social activity and aggressive behavior via its binding to oxytocin receptor (OXTR). Considering the multifactorial nature of developing aggression, the present study aimed to assess the main effects of the OXTR (rs53576, rs237911, rs7632287, rs2254298, rs2228485, rs13316193) gene polymorphisms together with haplotypic and G × E effects on individual differences in aggression level in 623 mentally healthy individuals with sex and ethnicity as covariates. The association of rs2228485*G allele (P_FDR = 0.046) and rs237911*G allele (P_FDR = 0.046) and decreased aggression level was observed in Tatars. Haplotypic analysis revealed an association of the OXTR G*G*G haplotype (rs53576, rs2228485, and rs237911) and diminished aggression level (P_perm = 0.020) in Tatars. As a result of multiple regression analysis, we observed the modulating effect of smoking and paternal overprotection significantly affecting association of the OXTR rs2228485 and aggression level (P = 0.029 and P = 0.014, respectively) in the total sample.

中文翻译：

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催产素受体（OXTR）基因多态性在健康个体攻击行为发展中的作用。

摘要

催产素通过与催产素受体（OXTR）结合，是调节社交活动和攻击行为的关键要素之一。考虑到发展性攻击的多因素性质，本研究旨在评估OXTR（rs53576，rs237911，rs7632287，rs2254298，rs2228485，rs13316193）基因多态性的主要作用，以及单倍型和G×E对个体攻击水平差异的影响623个心理健康的个体，性别和种族为协变量。的关联rs2228485 * G等位基因（P _FDR = 0.046）和rs237911 * G在Ta骨中观察到等位基因（P _FDR = 0.046）和降低的攻击水平。单倍型分析揭示了TR曲中OXTR G * G * G单倍型（rs53576，rs2228485和rs237911）的关联，并降低了Ta族的攻击水平（P _perm = 0.020）。多元回归分析的结果是，我们观察到吸烟和父亲过度保护的调节作用显着影响了总样本中OXTR rs2228485的关联和攻击水平（分别为P = 0.029和P = 0.014）。