Varicella and zoster, produced by varicella-zoster virus (VZV), are associated with an increased risk of stroke that may be due to persistent inflammation and hypercoagulability. Because substance P is associated with inflammation, hypercoagulability, and atherosclerotic plaque rupture that may contribute to increased stroke risk after VZV infection, we measured serum substance P in simian varicella virus–infected rhesus macaques. We found significantly increased and persistent serum substance P concentrations during varicella and zoster compared with pre-inoculation, supporting the hypothesis that VZV-induced increases in serum substance P may contribute to increased stroke risk associated with VZV infection.

由水痘-带状疱疹病毒 (VZV) 产生的水痘和带状疱疹与中风风险增加有关，这可能是由于持续的炎症和高凝状态。由于 P 物质与炎症、高凝状态和动脉粥样硬化斑块破裂有关，可能导致 VZV 感染后卒中风险增加，因此我们测量了猴水痘病毒感染的恒河猴的血清 P 物质。我们发现与接种前相比，水痘和带状疱疹期间血清 P 物质浓度显着增加且持续存在，这支持了 VZV 诱导的血清 P 物质增加可能导致与 VZV 感染相关的卒中风险增加的假设。