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Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications
International Journal of Nanomedicine ( IF 8 ) Pub Date : 2020-09-22 , DOI: 10.2147/ijn.s264498 Yi Zhang , Jiayao Bi , Jiayi Huang , Yanan Tang , Shouying Du , Pengyue Li
International Journal of Nanomedicine ( IF 8 ) Pub Date : 2020-09-22 , DOI: 10.2147/ijn.s264498 Yi Zhang , Jiayao Bi , Jiayi Huang , Yanan Tang , Shouying Du , Pengyue Li
Abstract: Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic acids, proteins, lipids and other bioactive substances to play a role in the body’s physiological and pathological processes. Compared to synthetic carriers such as liposomes and nanoparticles, the endogeneity and heterogeneity of exosomes give them extensive and unique advantages in the field of disease diagnosis and treatment. However, the storage stability, low yield, low purity, and weak targeting of exosomes limit its clinical application. For this reason, further exploration is needed to optimize the above problems and facilitate future functional studies of exosomes. In this paper, the origin, classification, preparation and characterization, storage stability and applications of exosome delivery system are summarized and discussed by searching a large number of literatures.
Keywords: exosomes, extraction and purification, storage stability, biomarkers, targeted drug delivery, surface modification
中文翻译:
外泌体:其分类,分离技术,储存,诊断和靶向治疗应用的综述
摘要:外来体是细胞分泌的纳米级小细胞外小泡,携带核酸,蛋白质,脂质和其他生物活性物质,在人体的生理和病理过程中发挥作用。与脂质体和纳米颗粒等合成载体相比,外泌体的内在性和异质性在疾病诊断和治疗领域具有广泛而独特的优势。然而,外来体的储存稳定性,低产量,低纯度和弱靶向性限制了其临床应用。因此,需要进一步探索以优化上述问题并促进未来的外泌体功能研究。本文对起源,分类,制备和表征,
关键词:外来体,提取和纯化,贮存稳定性,生物标志物,靶向药物递送,表面修饰
更新日期:2020-09-22
Keywords: exosomes, extraction and purification, storage stability, biomarkers, targeted drug delivery, surface modification
中文翻译:
外泌体:其分类,分离技术,储存,诊断和靶向治疗应用的综述
摘要:外来体是细胞分泌的纳米级小细胞外小泡,携带核酸,蛋白质,脂质和其他生物活性物质,在人体的生理和病理过程中发挥作用。与脂质体和纳米颗粒等合成载体相比,外泌体的内在性和异质性在疾病诊断和治疗领域具有广泛而独特的优势。然而,外来体的储存稳定性,低产量,低纯度和弱靶向性限制了其临床应用。因此,需要进一步探索以优化上述问题并促进未来的外泌体功能研究。本文对起源,分类,制备和表征,
关键词:外来体,提取和纯化,贮存稳定性,生物标志物,靶向药物递送,表面修饰