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Altered Brain Activity and Functional Connectivity in Unilateral Sudden Sensorineural Hearing Loss
Neural Plasticity ( IF 3.1 ) Pub Date : 2020-09-22 , DOI: 10.1155/2020/9460364 Jiawei Chen 1 , Bo Hu 2 , Peng Qin 3 , Wei Gao 1 , Chengcheng Liu 1 , Dingjing Zi 1 , Xuerui Ding 1 , Ying Yu 2 , Guangbin Cui 2 , Lianjun Lu 1
Neural Plasticity ( IF 3.1 ) Pub Date : 2020-09-22 , DOI: 10.1155/2020/9460364 Jiawei Chen 1 , Bo Hu 2 , Peng Qin 3 , Wei Gao 1 , Chengcheng Liu 1 , Dingjing Zi 1 , Xuerui Ding 1 , Ying Yu 2 , Guangbin Cui 2 , Lianjun Lu 1
Affiliation
Background. Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. This study is aimed at investigating brain functional changes in SSNHL via functional magnetic resonance imaging (fMRI). Methods. Thirty-six patients with SSNHL and thirty well-matched normal hearing individuals underwent resting-state fMRI. Amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and functional connectivity (FC) values were calculated. Results. In the SSNHL patients, ALFF and fALFF were significantly increased in the bilateral putamen but decreased in the right calcarine cortex, right middle temporal gyrus (MTG), and right precentral gyrus. Widespread increases in FC were observed between brain regions, mainly including the bilateral auditory cortex, bilateral visual cortex, left striatum, left angular gyrus (AG), bilateral precuneus, and bilateral limbic lobes in patients with SSNHL. No decreased FC was observed. Conclusion. SSNHL causes functional alterations in brain regions, mainly in the striatum, auditory cortex, visual cortex, MTG, AG, precuneus, and limbic lobes within the acute period of hearing loss.
中文翻译:
单侧突发感音神经性听力损失中大脑活动和功能连接的改变
背景。突发感音神经性听力损失 (SSNHL) 是一种耳科急症,可能导致某些患者出现社交困难和精神障碍。尽管许多研究分析了听力损失人群的大脑功能改变,但关于特发性 SSNHL 患者的信息很少。本研究旨在通过功能磁共振成像 (fMRI) 研究 SSNHL 的脑功能变化。方法。36 名 SSNHL 患者和 30 名匹配良好的正常听力个体接受了静息态 fMRI。计算低频波动幅度 (ALFF)、部分 ALFF (fALFF) 和功能连接 (FC) 值。结果. 在 SSNHL 患者中,双侧壳核的 ALFF 和 fALFF 显着增加,但在右侧距状皮质、右侧颞中回 (MTG) 和右侧中央前回中减少。在 SSNHL 患者的大脑区域之间观察到 FC 的广泛增加,主要包括双侧听觉皮层、双侧视觉皮层、左侧纹状体、左侧角回 (AG)、双侧楔前叶和双侧边缘叶。没有观察到减少的 FC。结论。SSNHL 导致大脑区域的功能改变,主要是在听力损失急性期的纹状体、听觉皮层、视觉皮层、MTG、AG、楔前叶和边缘叶。
更新日期:2020-09-22
中文翻译:
单侧突发感音神经性听力损失中大脑活动和功能连接的改变
背景。突发感音神经性听力损失 (SSNHL) 是一种耳科急症,可能导致某些患者出现社交困难和精神障碍。尽管许多研究分析了听力损失人群的大脑功能改变,但关于特发性 SSNHL 患者的信息很少。本研究旨在通过功能磁共振成像 (fMRI) 研究 SSNHL 的脑功能变化。方法。36 名 SSNHL 患者和 30 名匹配良好的正常听力个体接受了静息态 fMRI。计算低频波动幅度 (ALFF)、部分 ALFF (fALFF) 和功能连接 (FC) 值。结果. 在 SSNHL 患者中,双侧壳核的 ALFF 和 fALFF 显着增加,但在右侧距状皮质、右侧颞中回 (MTG) 和右侧中央前回中减少。在 SSNHL 患者的大脑区域之间观察到 FC 的广泛增加,主要包括双侧听觉皮层、双侧视觉皮层、左侧纹状体、左侧角回 (AG)、双侧楔前叶和双侧边缘叶。没有观察到减少的 FC。结论。SSNHL 导致大脑区域的功能改变,主要是在听力损失急性期的纹状体、听觉皮层、视觉皮层、MTG、AG、楔前叶和边缘叶。