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Recent progress of highly adhesive hydrogels as wound dressings.
Biomacromolecules ( IF 6.2 ) Pub Date : 2020-09-22 , DOI: 10.1021/acs.biomac.0c01069
Liwei Zhang 1, 2 , Min Liu 3 , Yajie Zhang 1 , Renjun Pei 1
Affiliation  

Wound dressings are widely used to promote wound healing. Traditional dressings need the help of tape to fix onto the wounds, which are not suitable in the human body. In addition, hemostasis of internal wounds is usually treated with direct sutures which will cause secondary trauma to the patient and increase the risk of infection. Therefore, development of new dressings with high tissue adhesion and biocompatibility is of great clinical significance. The highly adhesive wound dressings can firmly attach to external and internal wounds, and form a barrier to prevent bacterial invasion, accelerate healing, and avoid secondary damage caused by sutures. Hydrogels are soft materials that possess a 3D network structure with tunable physical and chemical properties, which provides ideal conditions to support the wound healing process. In this review, we summarize the recent advances in developing hydrogel-based wound dressings as well as their adhesion mechanism. Moreover, the prospects of these wound dressings over the coming years are also covered.

中文翻译:

高粘性水凝胶作为伤口敷料的最新进展。

伤口敷料被广泛用于促进伤口愈合。传统的敷料需要借助胶带将其固定在伤口上,这在人体中是不合适的。另外,内部伤口的止血通常用直接缝合来治疗,这将对患者造成继发性创伤并增加感染的风险。因此,开发具有高组织粘附性和生物相容性的新型敷料具有重要的临床意义。高粘性伤口敷料可以牢固地附着在外部和内部伤口上,并形成屏障以防止细菌入侵,加速愈合并避免缝合线造成的继发性损伤。水凝胶是具有3D网络结构且具有可调节的物理和化学特性的柔软材料,可提供理想的条件来支持伤口愈合过程。在这篇评论中 我们总结了开发基于水凝胶的伤口敷料及其粘附机制的最新进展。此外,还涵盖了这些伤口敷料在未来几年的前景。
更新日期:2020-10-12
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