Loss of cerebral autoregulation in normal perfusion pressure breakthrough (NPPB) phenomenon has been reported in other Central Nervous System diseases such as neonatal intraventricular haemorrhage. Several studies have demonstrated that low-dose indomethacin prevents this latter condition. A previous rat model was used to resemble NPPB phenomenon. Study animals were distributed in 4 groups that received 3 doses of indomethacin at different concentrations prior to fistula occlusion 60 days after its creation. Control animals received saline solution. Intracranial pressure (ICP) increased in all groups following fistula creation, whereas mean arterial pressure (MAP) and cerebral perfusion pressure (CPP) decreased as a manifestation of cerebral hypoperfusion and intracranial hypertension. The administration of indomethacin was associated with raised MAP and CPP, as well as decreased ICP. Sodium fluorescein extravasation was slight in study animals when comparing with control ones. Histological analysis evidenced diffuse ischaemic changes with signs of neuronal apoptosis in all brain layers in control animals. These findings were only focal and slight in study animals. The results suggest the usefulness of indomethacin to revert, at least partially, the haemodynamic effects of NPPB phenomenon in this experimental model, as well as to reduce BBB disruption and histological ischemia observed in absence of indomethacin.

在其他中枢神经系统疾病如新生儿脑室内出血中，已经报道了正常灌注压突破 (NPPB) 现象中大脑自动调节的丧失。几项研究表明，低剂量的吲哚美辛可预防后一种情况。以前的大鼠模型用于模拟 NPPB 现象。研究动物被分成 4 组，在瘘管形成后 60 天闭塞前接受 3 剂不同浓度的吲哚美辛。对照动物接受盐水溶液。瘘管形成后，所有组的颅内压 (ICP) 均升高，而平均动脉压 (MAP) 和脑灌注压 (CPP) 降低，这是脑灌注不足和颅内高压的表现。吲哚美辛的给药与升高的 MAP 和 CPP 以及降低的 ICP 相关。与对照动物相比，研究动物的荧光素钠外渗轻微。组织学分析表明，对照动物的所有脑层均出现弥漫性缺血变化，并伴有神经元凋亡的迹象。这些发现在研究动物中只是局部的和轻微的。结果表明，在该实验模型中，消炎痛至少部分地恢复了 NPPB 现象的血流动力学效应，以及减少了在不存在消炎痛的情况下观察到的 BBB 破坏和组织学缺血。组织学分析表明，对照动物的所有脑层均出现弥漫性缺血变化，并伴有神经元凋亡的迹象。这些发现在研究动物中只是局部的和轻微的。结果表明，在该实验模型中，消炎痛至少部分地恢复了 NPPB 现象的血流动力学效应，以及减少了在不存在消炎痛的情况下观察到的 BBB 破坏和组织学缺血。组织学分析表明，对照动物的所有脑层均出现弥漫性缺血变化，并伴有神经元凋亡的迹象。这些发现在研究动物中只是局部的和轻微的。结果表明，在该实验模型中，消炎痛至少部分地恢复了 NPPB 现象的血流动力学效应，以及减少了在不存在消炎痛的情况下观察到的 BBB 破坏和组织学缺血。