The present study describes a facile and solvent free synthesis of 1,2,4-triazine antipyrine derivatives (2a–f) in prominent yields (70–85%) over nucleophilic substitution of 5-carbonitrile triazines. Further, we strained to convert them into pyridine analogues (3a–f) over aza-Diels-Alder reaction with norbornadiene as dienophile but it was an unsuccessful attempt. It is an assumption we made that the antipyrine substituent primes the triazine electronically unfavorable at 1,2-aza position. All the synthesized compounds were confirmed by using ¹H NMR, ¹⁹F NMR, ¹³C NMR and Mass spectral studies. Furthermore, this stated synthetic approach is ecofriendly as there are no toxic intermediates and also, the antipyrine derivatives can be aiding as promising templates for the development of new pharmaceutical scaffolds.

本研究描述了1,2,4-三嗪安替比林衍生物（2a–f）的简便，无溶剂合成方法，其亲和力取代了5-甲腈三嗪，且收率很高（70–85％）。此外，我们力求通过降冰片二烯作为亲二烯体的氮杂-Diels-Alder反应将它们转化为吡啶类似物（3a–f），但这是一次失败的尝试。我们假设，安替比林取代基在1,2-氮杂位置引发了电子上不利的三嗪的引发。通过¹ H NMR，¹⁹ F NMR，¹³确认所有合成的化合物13 C NMR和质谱研究。此外，该陈述的合成方法是环保的，因为它没有毒性中间体，而且安替比林衍生物可以作为开发新的药物支架的有希望的模板。