During recent years, creatine kinase (CK) and its substrates phosphocreatine and creatine emerged as important players in uncoupling protein 1-independent, ATP-dependent non-shivering thermogenesis in beige/brown adipocytes. The exact thermogenic mechanism, that is facilitated by the CK system, however, still remains elusive. A futile creatine-cycling mechanism functioning via a hypothetical phosphocreatine phosphatase has been proposed. However, the molecular basis of such cycling remained elusive, so far. Here, we tend to argue for an alternative mechanism based on the classical CK/phosphocreatine shuttle and phosphocreatine-driven futile Ca²⁺-cycling at the endoplasmic reticulum.

中文翻译：

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肌酸和肌酸激酶在不依赖UCP1的脂肪细胞生热中的作用。

近年来，肌酸激酶（CK）及其底物磷酸肌酸和肌酸已成为解偶联米色/棕色脂肪细胞中不依赖蛋白质1的，不依赖ATP的非颤抖的生热作用的重要角色。但是，CK系统促进的确切的产热机理仍然难以捉摸。已经提出了通过假设的磷酸肌酸磷酸酶起作用的无效的肌酸循环机制。但是，到目前为止，这种循环的分子基础仍然难以捉摸。在这里，我们倾向于基于经典的CK /磷酸肌酸穿梭和内质网处磷酸肌酸驱动的无效Ca ²⁺循环的另一种机制。