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Host–guest interaction of cucurbit[8]uril with oroxin A and its effect on the properties of oroxin A
Beilstein Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2020-09-22 , DOI: 10.3762/bjoc.16.194
Zhishu Zeng 1 , Jun Xie 1 , Guangyan Luo 1 , Zhu Tao 1 , Qianjun Zhang 1
Affiliation  

In this study, we investigated the host–guest interactions between oroxin A (OA) and cucurbit[8]uril (Q[8]) using 1H NMR, MS, UV–vis and IR spectroscopy. The results showed that OA and Q[8] formed an inclusion compound (OA@Q[8]) with a molar ratio of 1:1 and a binding constant of 1.299 × 107 L·mol−1. In addition, the effect of Q[8] on the properties of OA was investigated through comparative experiments. The solubility of OA in water increased 22.47-fold when the concentration of Q[8] was 1 × 10−4 mol·L−1. Q[8] hardly affected the antioxidant capacity of OA, while the cumulative release of OA in gastric juice increased 2.3-fold after forming the inclusion compound with Q[8].

中文翻译:

葫芦[8]脲与oroxin A的主客体相互作用及其对oroxin A性质的影响

在本研究中,我们使用1 H NMR、MS、UV-vis 和 IR 光谱研究了 oroxin A (OA) 和葫芦[8]uril (Q[8]) 之间的主客体相互作用。结果表明,OA与Q[8]以1:1的摩尔比形成包合物(OA@Q[8]),结合常数为1.299×10 7 L ·mol -1。此外,通过对比实验研究了Q[8]对OA性能的影响。当Q[8]浓度为1×10 -4 mol·L -1时,OA在水中的溶解度增加了22.47倍。Q[8]对OA的抗氧化能力几乎没有影响,而与Q[8]形成包合物后,OA在胃液中的累积释放量增加了2.3倍。
更新日期:2020-09-22
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